Incidence and impact of disseminated intravascular coagulation in COVID-19 a systematic review and meta-analysis

被引：40
作者：
Zhou, Xianghui [1 ,2 ]
Cheng, Zhipeng [1 ,2 ]
Luo, Lili [1 ,2 ]
Zhu, Ying [3 ]
Lin, Wenyi [1 ,2 ]
Ming, Zhangyin [3 ,4 ]
Chen, Wei [6 ]
Hu, Yu [1 ,2 ,5 ]
机构：
[1] Huazhong Univ Sci & Technol, Dept Hematol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China
[2] Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Hematol, Wuhan 430022, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Sch Basic Med, Dept Pharmacol, Tongji Med Coll, Wuhan 430022, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Rongcheng Ctr Biomed, Wuhan 430022, Peoples R China
[5] Hubei Clin Med Ctr Cell Therapy Neoplast Dis, Wuhan 430022, Hubei, Peoples R China
[6] Beijing Inst Biotechnol, Lab Vaccine & Antibody Engn, Beijing 100071, Peoples R China
来源：
THROMBOSIS RESEARCH | 2021年 / 201卷
基金：
中国国家自然科学基金;
关键词：
Coronavirus disease 2019 (COVID-19); SARS-CoV-2; Disseminated intravascular coagulation; CORONAVIRUS DISEASE 2019; CLINICAL CHARACTERISTICS; COAGULOPATHY; PROGNOSIS; WUHAN;
D O I：
10.1016/j.thromres.2021.02.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: Coronavirus disease 2019 (COVID-19) is a novel infectious disease, with significant morbidity and mortality. This meta-analysis is to evaluate the prevalence of disseminated intravascular coagulation (DIC) in COVID-19 patients and to determine the association of DIC with the severity and prognosis of COVID-19. Methods: We searched the PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) database until August 12, 2020. The meta-analysis was performed using Stata 16.0 software. Results: 14 studies were included in our meta-analysis. The pooled analysis revealed that the incidence of COVID19 patients developing DIC was 3% (95%: 1%?5%, P < 0.001). In addition, deaths were more likely to be associated with DIC (Log OR = 2.46, 95% CI: 0.94?3.99, P < 0.001) with statistical significance. Conclusions: DIC is associated with the severity and poor prognosis of COVID-19 patients. Therefore, attention should be paid to coagulation dysfunction in COVID-19 patients. Monitoring of coagulation indicators may improve the prognosis of COVID-19 inpatients.
引用
收藏
页码：23 / 29
页数：7
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