Application of molecular diagnostic techniques to renal epithelial neoplasms

被引：34
作者：
Jones, TD [1 ]
Eble, JN [1 ]
Cheng, L [1 ]
机构：
[1] Indiana Univ, Sch Med, Dept Pathol & Lab Med, Med Ctr,Univ Hosp, Indianapolis, IN 46202 USA
来源：
CLINICS IN LABORATORY MEDICINE | 2005年 / 25卷 / 02期
关键词：
D O I：
10.1016/j.cll.2005.01.011
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Molecular and cytogenetic techniques have been used extensively to study the genetics of renal epithelial neoplasia. Several genes and chromosomal aberrations have been identified that play important roles in the development and progression of kidney tumors. Each histologic type of renal neoplasm is characterized by specific types of genetic alterations, a finding that can aid in making correct diagnoses in difficult cases. In addition, molecular genetic research in renal cell tumors continues to: (1) assist in our understanding of the nature and causes of tumorigenesis and tumor progression, (2) further the assessment of prognosis, (3) facilitate early detection, (4) lead to advances in therapy, and (5) help guide treatment.
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页码：279 / +
页数：26
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