Impact of Huntington's disease on quality of life

被引：74

作者：

Helder, DI

Kaptein, AA

van Kempen, GMJ

van Houwelingen, JC

Roos, RAC

机构：

[1] Leiden Univ, Med Ctr, Dept Psychiat, NL-1240 BG Oegstgeest, Netherlands

[2] Leiden Univ, Med Ctr, Dept Med Stat, NL-1240 BG Oegstgeest, Netherlands

[3] Leiden Univ, Med Ctr, Dept Neurol, NL-1240 BG Oegstgeest, Netherlands

来源：

MOVEMENT DISORDERS | 2001年 / 16卷 / 02期

关键词：

Huntington's disease; quality of lift; Sickness Impact Profile;

D O I：

10.1002/mds.1056

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The purpose of this study was to systematically as sess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP). Additional data were gathered on patients motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, bur not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed, (C) 2001 Movement Disorder Society.

引用

页码：325 / 330

页数：6

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