Development of a novel inducer of protein-protein interactions based on aplyronine A

被引：9
|
作者：
Ohyoshi, Takayuki [1 ]
Takano, Atsuhiro [1 ]
Namiki, Mayu [1 ]
Ogura, Tomotaka [1 ]
Miyazaki, Yuto [1 ]
Ebihara, Yuta [1 ]
Takeno, Koichi [1 ]
Hayakawa, Ichiro [2 ]
Kigoshi, Hideo [1 ]
机构：
[1] Univ Tsukuba 1 1 1 Tennodai, Grad Sch Pure & Appl Sci, Dept Chem, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058571, Japan
[2] Okayama Univ, Grad Sch Nat Sci & Technol, Div Appl Chem, Kita Ku, 3-1-1 Tsushima Naka, Okayama 7008530, Japan
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 68期
基金：
日本学术振兴会;
关键词：
POTENT ANTITUMOR MACROLIDE; SPONGE THEONELLA-SWINHOEI; ACTIN-DEPOLYMERIZING ACTIVITY; MARINE NATURAL-PRODUCTS; HARE APLYSIA-KURODAI; CYTOTOXIC MACROLIDE; MYCALOLIDE ANALOGS; ARTIFICIAL ANALOGS; ORIGIN; SUBSTANCE;
D O I：
10.1039/c8cc04613a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An aplyronine A-swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein-protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.
引用
收藏
页码：9537 / 9540
页数：4
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