Resistance of spores of Bacillus species to ultraviolet light

被引:144
作者
Setlow, P [1 ]
机构
[1] Univ Connecticut, Ctr Hlth, Dept Biochem, Farmington, CT 06032 USA
关键词
bacillus subtilis; DNA repair; spore photoproduct; spores; UV resistance;
D O I
10.1002/em.1058
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Dormant spores of the various Bacillus species, including B. subtilis, are 5 to 50 times more resistant to UV radiation than are the corresponding growing cells. This elevated spore UV resistance is due to: a) the photochemistry of DNA within spores, as UV generates few if any cyclobutane dimers, but rather a photoproduct (Fig. 1) called spore photoproduct (SP; 5-thyminyl-5,6-dihydrothymine); and b) DNA repair, in particular SP-specific repair, during spore germination. The novel UV photochemistry of spore DNA is largely due to its saturation with a group of small, acid-soluble proteins (SASP), which are unique to spores and whose binding alters the DNA conformation and thus its photochemistry. SP-specific repair is also unique to spores and is carried out by alight-independent SP-lyase, an iron-sulfur protein that utilizes S-adenosylmethionine to catalyze SP monomerization without DNA backbone cleavage. Environ. Mol. Mutagen. (C) 2001 Wiley-Liss, Inc.
引用
收藏
页码:97 / 104
页数:8
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