Microvesicles as Novel Biomarkers and Therapeutic Targets in Transplantation Medicine

被引：51

作者：

Fleissner, F. ^{[1
,2
]}

Goerzig, Y. ^{[1
]}

Haverich, A. ^{[2
]}

Thum, T. ^{[1
,3
]}

机构：

[1] Hannover Med Sch, IMTTS, D-3000 Hannover, Germany

[2] Hannover Med Sch, Div Cardiac Thorac Transplantat & Vasc Surg, D-3000 Hannover, Germany

[3] IRCCS San Raffaele, Ctr Clin & Basic Res, Rome, Italy

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2012年 / 12卷 / 02期

关键词：

Exosomes; gene transfer; microvesicles; solid organ transplantation; PLATELET-DERIVED MICROPARTICLES; FAS LIGAND; CIRCULATING MICRORNAS; HORIZONTAL TRANSFER; INDUCE APOPTOSIS; GENE-EXPRESSION; CANCER-CELLS; EXOSOMES; SECRETION; VESICLES;

D O I：

10.1111/j.1600-6143.2011.03790.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Microvesicles (MVs) including exosomes are emerging new biomarkers and potential regulators of inflammation and immunological processes. Such particles contain proteins and genetic information including DNA and microRNAs that may be of importance for cell/cell communication. However, their role during and after organ transplantation and immunomodulatory effects is only in its beginning of understanding. We here, in brief, introduce generation and biological importance of MVs, describe their (patho)physiological roles and their potential use as future biomarkers and therapeutic agents in transplantation medicine. Circulating MVs may have a great potential to detect possible immune rejections and MV modulation may emerge as a therapeutic approach in organ rejection therapy.

引用

页码：289 / 297

页数：9

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