A new heart: Somatic stem cells and myocardial regeneration

被引：4
作者：
Mullenix, Philip S. [1 ,2 ]
Huddleston, Steven J. [3 ]
Stojadinovic, Alexander [1 ]
Trachiotis, Gregory D. [2 ,4 ]
Alexander, Edmund P. [2 ]
机构：
[1] Walter Reed Army Med Ctr, Dept Surg, Div Cardiothorac Surg, Washington, DC 20307 USA
[2] Vet Affairs Med Ctr, Dept Surg, Washington, DC 20422 USA
[3] Johns Hopkins Univ, Med Ctr, Baltimore, MD 21218 USA
[4] George Washington Univ, Med Ctr, Dept Surg, Washington, DC 20037 USA
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2012年 / 105卷 / 05期
关键词：
myocardial infarction; somatic stem cells; heart failure; myocardial regeneration; COLONY-STIMULATING FACTOR; FRONT-INTEGRATED REVASCULARIZATION; PROGENITOR CELLS; DOUBLE-BLIND; TRANSCORONARY TRANSPLANTATION; INTRACORONARY TRANSPLANTATION; INFARCTION; MOBILIZATION; FAILURE; POPULATION;
D O I：
10.1002/jso.23014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
End-stage heart failure is a global scourge. Current therapies merely delay its inexorable progression. Heart transplantation is resource-intensive and limited by organ availability. Bone marrow-derived and cardiac-specific stem cells have demonstrated potential for cardiac regeneration and repair, but the magnitude and durability of these promising findings are inconsistent. The purpose of this review is to (1) describe cells currently being investigated, (2) outline the status of current trials, and (3) discuss key objectives of future research. J. Surg. Oncol. 2012; 105:475480. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：475 / 480
页数：6
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