Identification of murine T-cell epitopes in Ebola virus nucleoprotein

被引：24

作者：

Simmons, G ^{[1
]}

Lee, A ^{[1
]}

Rennekamp, AJ ^{[1
]}

Fan, X ^{[1
]}

Bates, P ^{[1
]}

Shen, H ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

来源：

VIROLOGY | 2004年 / 318卷 / 01期

关键词：

Ebola; CD8 T cells; MHC class I epitope; vaccine; heterologous prime/boost;

D O I：

10.1016/j.virol.2003.09.016

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

CD8 T cells play an important role in controlling Ebola infection and in mediating vaccine-induced protective immunity, yet little is known about antigenic targets in Ebola that are recognized by CD8 T cells. Overlapping peptides were used to identify major histocompatibility complex class I-restricted epitopes in mice immunized with vectors encoding Ebola nucleoprotein (NP). CD8 T-cell responses were mapped to a H-2(d)-restricted epitope (NP279-288) and two H-2(b)-restricted epitopes (NP44-52 and NP288-296). The identification of these epitopes will facilitate studies of immune correlates of protection and the evaluation of vaccine strategies in murine models of Ebola infection. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：224 / 230

页数：7

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