Recombinant Human TSH Increases Uptake and Effective Half-life of Radioiodine in Thyroid Hormone Secreting Metastases of Follicular Thyroid Cancer

被引：4
|
作者：
Schneider, C. [1 ]
Dietlein, M. [1 ]
Eschner, W. [2 ]
Schmidt, M. [1 ]
Kahraman, D. [1 ]
Kobe, C. [1 ]
机构：
[1] Univ Hosp Cologne, Dept Nucl Med, D-50937 Cologne, Germany
[2] Univ Cologne, Dept Nucl Med, D-50931 Cologne, Germany
来源：
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2012年 / 120卷 / 03期
关键词：
follicular thyroid cancer; thyroid hormone secreting metastases; radioiodine therapy; rhTSH; CARCINOMA; HYPERTHYROIDISM; RECOMMENDATIONS; DIAGNOSIS;
D O I：
10.1055/s-0031-1299710
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Follicular thyroid cancer with thyroid hormone secreting metastases is an extremely rare condition, with only a few cases reported world-wide. We here present the case of a 64-year-old female patient affected by follicular thyroid cancer with extensive thyroid hormone secreting metastases leading to TSH-suppression. We have also summarized the relevant diagnostic and therapeutic approaches and describe, for the first time, the effects of rhTSH-application in this rare tumor entity. In this patient, we found that rhTSH increased I-131-uptake into the thyroid hormone secreting metastases and prolonged the effective half-life of I-131. These effects of rhTSH should be considered when fixed activities of I-131 are prescribed.
引用
收藏
页码：160 / 163
页数：4
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