Recombinant Human TSH Increases Uptake and Effective Half-life of Radioiodine in Thyroid Hormone Secreting Metastases of Follicular Thyroid Cancer

被引：4

作者：

Schneider, C. ^{[1
]}

Dietlein, M. ^{[1
]}

Eschner, W. ^{[2
]}

Schmidt, M. ^{[1
]}

Kahraman, D. ^{[1
]}

Kobe, C. ^{[1
]}

机构：

[1] Univ Hosp Cologne, Dept Nucl Med, D-50937 Cologne, Germany

[2] Univ Cologne, Dept Nucl Med, D-50931 Cologne, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2012年 / 120卷 / 03期

关键词：

follicular thyroid cancer; thyroid hormone secreting metastases; radioiodine therapy; rhTSH; CARCINOMA; HYPERTHYROIDISM; RECOMMENDATIONS; DIAGNOSIS;

D O I：

10.1055/s-0031-1299710

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Follicular thyroid cancer with thyroid hormone secreting metastases is an extremely rare condition, with only a few cases reported world-wide. We here present the case of a 64-year-old female patient affected by follicular thyroid cancer with extensive thyroid hormone secreting metastases leading to TSH-suppression. We have also summarized the relevant diagnostic and therapeutic approaches and describe, for the first time, the effects of rhTSH-application in this rare tumor entity. In this patient, we found that rhTSH increased I-131-uptake into the thyroid hormone secreting metastases and prolonged the effective half-life of I-131. These effects of rhTSH should be considered when fixed activities of I-131 are prescribed.

引用

页码：160 / 163

页数：4

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