One-pot synthesis of tertiary alkyl fluorides from methyl oxalates by radical deoxyfluorination under photoredox catalysis

被引：28

作者：

Brioche, Julien ^{[1
]}

机构：

[1] UNIROUEN, Normandie Univ, INSA Rouen, CNRS,COBRA, F-76000 Rouen, France

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 50期

关键词：

Radical fluorination; Photoredox catalysis; Deoxyfluorinarion; Tertiary alkyl fluorides; C-H FLUORINATION; ALIPHATIC CARBOXYLIC-ACIDS; DECARBOXYLATIVE FLUORINATION; BOND FORMATION; ALCOHOLS; TRIFLUOROMETHYLATION; ACTIVATION; CENTERS; MONO;

D O I：

10.1016/j.tetlet.2018.10.063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tertiary alkyl fluorides have been prepared from methyl oxalates derived from tertiary alcohols by a sequential one-pot hydrolysis/photoredox catalyzed radical deoxyfluorination sequence. The reaction operates under mild conditions and tolerates a wide range of functional groups. This method provides an alternative approach to ionic deoxyfluorination transformations for the incorporation of Carbone-Fluorine quaternary centers into organic molecules. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：4387 / 4391

页数：5

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