High-sensitivity troponin T and I in patients suspected of acute myocardial infarction

被引：4

作者：

Kleemeier, Steffan ^{[1
]}

Abildgaard, Anders ^{[2
]}

Ladefoged, Soren Andreas ^{[2
]}

Sorensen, Jacob Thorsted ^{[3
]}

Stengaard, Carsten ^{[3
]}

Adelborg, Kasper ^{[1
,2
,4
]}

机构：

[1] Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus, Denmark

[2] Aarhus Univ Hosp, Dept Clin Biochem, Olof Palmes Alle 43-45, DK-8200 Aarhus N, Denmark

[3] Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark

[4] Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2022年 / 82卷 / 02期

关键词：

Myocardial infarction; acute coronary syndrome; coronary artery disease; high-sensitivity troponin; diagnosis; prognosis; ACUTE CORONARY SYNDROME; CARDIAC TROPONIN; ELEVATION; SYSTEM;

D O I：

10.1080/00365513.2022.2033310

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Measurement of cardiac troponin (cTn) is the cornerstone in the diagnosis of myocardial infarction (MI). Potential disparities in concentrations of cTn, trajectories and mortality, following initial measurement warrant further investigation. Such data may guide clinicians treating patients suspected of MI. Plasma concentrations of cTnT and cTnI were measured in 503 consecutive patients at Aarhus University Hospital between June 13th and June 27th, 2019. cTnT was measured with the Roche cobas (R) E602 hs-cTnT assay, while cTnI was measured with the Siemens ADVIA Centaur(R) XPT hs-cTnI assay. Analytical agreement was determined based on assay-specific 99(th) percentiles. Medical records were reviewed for adjudication of the MI diagnosis. MI was the final diagnosis in 65 patients (12.9%) and the analytical agreement between cTnT and cTnI assays was 95.2%. For patients diagnosed with MI, cTnI reached higher peak concentrations in shorter time, compared to cTnT. All-cause mortality risk increased with increasing levels of both biomarkers. In this study, the analytical agreement of two cTn assays was high. However, some disparities in troponin trajectories were observed.

引用

页码：96 / 103

页数：8

共 24 条

[1]

Aarhus University Hospital, FACTS AUH

[2] Troponin elevation in coronary vs. non-coronary disease [J].

Agewall, S. ;

Giannitsis, E. ;

Jernberg, T. ;

Katus, H. .

EUROPEAN HEART JOURNAL, 2011, 32 (04) :404-411B

[3]

Allan SJ., TROPONIN TESTING ANA

[4] Existing Data Sources in Clinical Epidemiology: Laboratory Information System Databases in Denmark [J].

Arendt, Johan Frederik Hakonsen ;

Hansen, Anette Tarp ;

Ladefoged, Soren Andreas ;

Sorensen, Henrik Toft ;

Pedersen, Lars ;

Adelborg, Kasper .

CLINICAL EPIDEMIOLOGY, 2020, 12 :469-475

[5] High-Sensitivity Cardiac Troponin I Assay for Early Diagnosis of Acute Myocardial Infarction [J].

Boeddinghaus, Jasper ;

Nestelberger, Thomas ;

Twerenbold, Raphael ;

Koechlin, Luca ;

Meier, Mario ;

Troester, Valentina ;

Wussler, Desiree ;

Badertscher, Patrick ;

Wildi, Karin ;

Puelacher, Christian ;

de Lavallaz, Jeanne du Fay ;

Gimenez, Maria Rubini ;

Zimmermann, Tobias ;

Hafner, Benjamin ;

Potlukova, Eliska ;

Miro, Oscar ;

Javier Martin-Sanchez, F. ;

Keller, Dagmar, I ;

Reichlin, Tobias ;

Mueller, Christian ;

Walter, Joan Elias ;

Strebe, No ;

Kozhuharov, Nikola ;

Freese, Michael ;

Fuenzalida, Carolina ;

Stelzig, Claudia ;

Gualandro, Danielle M. ;

Michou, Eleni ;

Meissner, Kathrin ;

Kulangara, Caroline ;

Shrestha, Samyut ;

Fahrni, Regor ;

Osswald, Stefan ;

Lopez, Beatriz ;

Rodriguez Adrada, Esther ;

Ganovska, Eva ;

Lohrmann, Jens ;

Kloos, Wanda ;

Steude, Jana ;

User, Andreas B. ;

von Eckardstein, Arnold ;

Morawiec, Beata ;

Kawecki, Damian ;

Nowalany-Kozielska, Ewa ;

Muzyk, Piotr ;

Geigy, Nicolas ;

Rentsch, Katharina .

CLINICAL CHEMISTRY, 2019, 65 (07) :893-904

[6] Predicting Acute Myocardial Infarction with a Single Blood Draw [J].

Boeddinghaus, Jasper ;

Nestelberger, Thomas ;

Badertscher, Patrick ;

Twerenbold, Raphael ;

Fitze, Brigitte ;

Wussler, Desiree ;

Strebel, Ivo ;

Gimenez, Maria Rubini ;

Wildi, Karin ;

Puelacher, Christian ;

de Lavallaz, Jeanne du Fay ;

Oehen, Loris ;

Walter, Joan ;

Miro, Oscar ;

Javier Martin-Sanchez, F. ;

Morawiec, Beata ;

Potlukova, Eliska ;

Keller, Dagmar, I ;

Reichlin, Tobias ;

Mueller, Christian ;

Sabti, Zaid ;

Freese, Michael ;

Stelzig, Claudia ;

Shrestha, Samyut ;

Schaerli, Nicolas ;

Kozhuharov, Nikola ;

Flores, Dayana ;

Lohrmann, Jens ;

Biskup, Ewalina ;

Kloos, Wanda ;

Osswald, Stefan ;

Mueller, Deborah ;

Sazgary, Lorraine ;

Lopez, Beatriz ;

Adrada, Esther Rodriguez ;

Kawecki, Damian ;

Muzyk, Piotr ;

Nowalany-Kozielska, Ewa ;

Parenica, Jiri ;

Ganovska, Eva ;

Meissner, Kathrin ;

Kulangara, Caroline ;

Mahfouz, Riham ;

Hartmann, Beate ;

Ferel, Ina ;

Campodarve, Isabel ;

Rentsch, Katharina ;

von Eckardstein, Arnold ;

Buser, Andreas ;

Geigy, Nicolas .

CLINICAL CHEMISTRY, 2019, 65 (03) :437-450

[7] Clinical Validation of a Novel High-Sensitivity Cardiac Troponin I Assay for Early Diagnosis of Acute Myocardial Infarction [J].

Boeddinghaus, Jasper ;

Twerenbold, Raphael ;

Nestelberger, Thomas ;

Badertscher, Patrick ;

Wildi, Karin ;

Puelacher, Christian ;

de Lavallaz, Jeanne du Fay ;

Keser, Elif ;

Gimenez, Maria Rubini ;

Wussler, Desiree ;

Kozhuharov, Nikola ;

Rentsch, Katharina ;

Miro, Oscar ;

Martin-Sanchez, F. Javier ;

Morawiec, Beata ;

Stefanelli, Sabrina ;

Geigy, Nicolas ;

Keller, Dagmar I. ;

Reichlin, Tobias ;

Mueller, Christian .

CLINICAL CHEMISTRY, 2018, 64 (09) :1347-1360

[8] High-Sensitivity Cardiac Troponin I and Clinical Risk Scores in Patients With Suspected Acute Coronary Syndrome [J].

Chapman, Andrew R. ;

Hesse, Kerrick ;

Andrews, Jack ;

Lee, Kuan Ken ;

Anand, Atul ;

Shah, Anoop S. V. ;

Sandeman, Dennis ;

Ferry, Amy V. ;

Jameson, Jack ;

Piya, Simran ;

Stewart, Stacey ;

Marshall, Lucy ;

Strachan, Fiona E. ;

Gray, Alasdair ;

Newby, David E. ;

Mills, Nicholas L. .

CIRCULATION, 2018, 138 (16) :1654-1665

[9] Increases of Cardiac Troponin in Conditions other than Acute Coronary Syndrome and Heart Failure [J].

Kelley, Walter E. ;

Januzzi, James L. ;

Christenson, Robert H. .

CLINICAL CHEMISTRY, 2009, 55 (12) :2098-2112

[10] High-Sensitivity Troponin T vs I in Acute Coronary Syndrome: Prediction of Significant Coronary Lesions and Long-term Prognosis [J].

Kvisvik, Brede ;

Morkrid, Lars ;

Rosjo, Helge ;

Cvancarova, Milada ;

Rowe, Alexander D. ;

Eek, Christian ;

Bendz, Bjorn ;

Edvardsen, Thor ;

Gravning, Jorgen .

CLINICAL CHEMISTRY, 2017, 63 (02) :552-562

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