Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection

被引：276

作者：

Harker, James A. ^{[1
]}

Lewis, Gavin M. ^{[1
]}

Mack, Lauren ^{[1
]}

Zuniga, Elina I. ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

来源：

SCIENCE | 2011年 / 334卷 / 6057期

关键词：

DENDRITIC CELLS; SERUM LEVELS; IN-VIVO; VIRUS; MICE; IL-6; INDUCTION; IMMUNE; BCL6; DIFFERENTIATION;

D O I：

10.1126/science.1208421

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Multiple inhibitory molecules create a profoundly immunuosuppressive environment during chronic viral infections in humans and mice. Therefore, eliciting effective immunity in this context represents a challenge. Here, we report that during a murine chronic viral infection, interleukin-6 (IL-6) was produced by irradiation-resistant cells in a biphasic manner, with late IL-6 being absolutely essential for viral control. The underlying mechanism involved IL-6 signaling on virus-specific CD4 T cells that caused up-regulation of the transcription factor Bcl6 and enhanced T follicular helper cell responses at late, but not early, stages of chronic viral infection. This resulted in escalation of germinal center reactions and improved antibody responses. Our results uncover an antiviral strategy that helps to safely resolve a persistent infection in vivo.

引用

页码：825 / 829

页数：5

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