p65/RelA-Ser529 NF-κB Subunit Phosphorylation Induces Autophagic Astroglial Death (Clasmatodendrosis) Following Status Epilepticus

被引：49

作者：

Ryu, Hea Jin ^{[1
,2
]}

Kim, Ji-Eun ^{[1
,2
]}

Yeo, Seong-Il ^{[1
,2
]}

Kang, Tae-Cheon ^{[1
,2
]}

机构：

[1] Hallym Univ, Dept Anat & Neurobiol, Coll Med, Chunchon 200702, South Korea

[2] Hallym Univ, Coll Med, Inst Epilepsy, Chunchon 200702, South Korea

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2011年 / 31卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

TNF-alpha; p65/RelA-Ser529; LAMP-1; LC3-II; Beclin-1; TEMPORAL-LOBE EPILEPSY; PROGRAMMED CELL-DEATH; RAT DENTATE GYRUS; BRAIN; ISCHEMIA; HIPPOCAMPUS; MECHANISMS; BECLIN-1; ACTIVATION; ASTROCYTES;

D O I：

10.1007/s10571-011-9706-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Clasmatodendrosis is an irreversible astroglial degenerative change, which includes extensive swelling and vacuolization of cell bodies and disintegrated and beaded processes. This study was designed to elucidate whether clasmatodendrosis may be one of the autophagy-related degeneration of astrocytes. In this study, clasmatodendritic astrocytes were observed only in the stratum radiatum in the CA1 region. Vacuoles in clasmatodendritic astrocytes showed LAMP-1 immunoreactivity. In addition, both LC3-II and Beclin-1 expression were detected in most of clasmatodendritic astrocytes as well as a few non-vacuolized astrocytes. Clasmatodendritic astrocytes also showed p65/RelA-Ser529 phosphorylation in the nuclei. The neutralization of TNF-alpha by sTNFp55R infusion reduced clasmatodendritic astrocytes with nuclear p65/RelA-Ser529 phosphorylation. Therefore, these findings suggest that clasmatodendrosis may be autophagic astroglial death in response to epileptic seizures through TNF-alpha-mediated p65/RelA-Ser529 phosphorylation.

引用

页码：1071 / 1078

页数：8

共 49 条

[1] Glia: The many ways to modulate synaptic plasticity [J].

Achour, S. Ben ;

Pascual, O. .

NEUROCHEMISTRY INTERNATIONAL, 2010, 57 (04) :440-445

[2] Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21 [J].

Aita, VM ;

Liang, XH ;

Murty, VVVS ;

Pincus, DL ;

Yu, WP ;

Cayanis, E ;

Kalachikov, S ;

Gilliam, TC ;

Levine, B .

GENOMICS, 1999, 59 (01) :59-65

[3] EARLY-LIFE UNDERNUTRITION CAUSES DEFICITS IN RAT DENTATE GYRUS GRANULE CELL NUMBER [J].

BEDI, KS .

EXPERIENTIA, 1991, 47 (10) :1073-1074

[4] RETRACTED: Signaling through P2X7 receptor in human T cells involves p56lck, kinases, and transcription factors AP-1 and NF-κB (Retracted Article. See vol 286, pg 9894, 2011) [J].

Budagian, V ;

Bulanova, E ;

Brovko, L ;

Orinska, Z ;

Fayad, R ;

Paus, R ;

Bulfone-Paus, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) :1549-1560

[5] Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy [J].

Bursch, W ;

Ellinger, A ;

Kienzl, H ;

Torok, L ;

Pandey, S ;

Sikorska, M ;

Walker, R ;

Hermann, RS .

CARCINOGENESIS, 1996, 17 (08) :1595-1607

[6] The ubiquitin proteolytic system - From a vague idea, through basic mechanisms, and onto human diseases and drug targeting [J].

Ciechanover, A .

NEUROLOGY, 2006, 66 :S7-S19

[7] DEVELOPMENTAL CELL-DEATH - MORPHOLOGICAL DIVERSITY AND MULTIPLE MECHANISMS [J].

CLARKE, PGH .

ANATOMY AND EMBRYOLOGY, 1990, 181 (03) :195-213

[8] Autophagy and signaling: their role in cell survival and cell death [J].

Codogno, P ;

Meijer, AJ .

CELL DEATH AND DIFFERENTIATION, 2005, 12 (Suppl 2) :1509-1518

[9] Ultrastructural study of rat hippocampus after chronic administration of aluminum L-glutamate: an acceleration of the aging process [J].

Deloncle, R ;

Huguet, F ;

Fernandez, B ;

Quellard, N ;

Babin, P ;

Guillard, O .

EXPERIMENTAL GERONTOLOGY, 2001, 36 (02) :231-244

[10] Neurotransmitter transporters expressed in glial cells as regulators of synapse function [J].

Eulenburg, Volker ;

Gomeza, Jesus .

BRAIN RESEARCH REVIEWS, 2010, 63 (1-2) :103-112

← 1 2 3 4 5 →