The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses

被引：15

作者：

Loewendorf, Andrea I. ^{[2
]}

Steinbrueck, Lars ^{[1
]}

Peter, Christoph ^{[1
]}

Busche, Andreas ^{[1
]}

Benedict, Chris A. ^{[2
]}

Kay-Jackson, Penelope C. ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Virol, D-30625 Hannover, Germany

[2] La Jolla Inst Allergy & Immunol, Div Immune Regulat, La Jolla, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 10期

关键词：

MHC CLASS-I; MURINE CYTOMEGALOVIRUS; DENDRITIC CELLS; ANTIGEN PRESENTATION; LIGAND; INFECTION; ACTIVATION; DIFFERENTIATION; MACROPHAGES; MOLECULES;

D O I：

10.1128/JVI.02178-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cytomegaloviruses (CMV) utilize a variety of immunomodulatory strategies to facilitate the establishment of lifelong persistence in their infected hosts. We show that the mouse CMV (MCMV) m155 open reading frame (ORF) is required for the posttranscriptional inhibition of CD40 expression in infected antigen-presenting cells. Consistent with the known importance of CD40-mediated costimulation of T cells, a m155-deficient virus induces enhanced MCMV epitope-specific CD4 T cell responses.

引用

页码：5208 / 5212

页数：5

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