The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses

被引：15

作者：

Loewendorf, Andrea I. ^{[2
]}

Steinbrueck, Lars ^{[1
]}

Peter, Christoph ^{[1
]}

Busche, Andreas ^{[1
]}

Benedict, Chris A. ^{[2
]}

Kay-Jackson, Penelope C. ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Virol, D-30625 Hannover, Germany

[2] La Jolla Inst Allergy & Immunol, Div Immune Regulat, La Jolla, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 10期

关键词：

MHC CLASS-I; MURINE CYTOMEGALOVIRUS; DENDRITIC CELLS; ANTIGEN PRESENTATION; LIGAND; INFECTION; ACTIVATION; DIFFERENTIATION; MACROPHAGES; MOLECULES;

D O I：

10.1128/JVI.02178-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cytomegaloviruses (CMV) utilize a variety of immunomodulatory strategies to facilitate the establishment of lifelong persistence in their infected hosts. We show that the mouse CMV (MCMV) m155 open reading frame (ORF) is required for the posttranscriptional inhibition of CD40 expression in infected antigen-presenting cells. Consistent with the known importance of CD40-mediated costimulation of T cells, a m155-deficient virus induces enhanced MCMV epitope-specific CD4 T cell responses.

引用

页码：5208 / 5212

页数：5

共 50 条

[21] Doxorubicin enhances CD4+ T-cell immune responses by inducing expression of CD40 ligand and 4-1BB
Park, Jae Yeo
Jang, Min Ja
Chung, Yoon Hee
Kim, Kyung Yong
Kim, Sung Su
Lee, Won Bok
You, Seungkwon
Choi, Youn Seok
Hur, Dae Young
Kim, Daejin
INTERNATIONAL IMMUNOPHARMACOLOGY, 2009, 9 (13-14) : 1530 - 1539
[22] CD4 T cell memory of prior influenza infections regulate new CD4 and CD8 T cell responses
Jelley-Gibbs, Dawn M.
McKinstry, Kai
Strutt, Tara
Dibble, John
Swain, Susan
JOURNAL OF IMMUNOLOGY, 2007, 178
[23] Regulation of CD40 ligand expression on naive CD4 T cells: A role for TCR but not co-stimulatory signals
Jaiswal, AI
Dubey, C
Swain, SL
Croft, M
INTERNATIONAL IMMUNOLOGY, 1996, 8 (02) : 275 - 285
[24] CD4 T cell responses to influenza infection
Brown, DM
Román, E
Swain, SL
SEMINARS IN IMMUNOLOGY, 2004, 16 (03) : 171 - 177
[25] CD40 is Required For Protective T Cell Responses Against Cryptosporidium
O'Dea, Keenan
Hunter, Christopher A.
JOURNAL OF IMMUNOLOGY, 2022, 208 (01):
[26] CD40 antibody as an adjuvant induces enhanced T cell responses
Carlring, J
Barr, TA
McCormick, AL
Health, AW
VACCINE, 2004, 22 (25-26) : 3323 - 3328
[27] CYCLOSPORINE-A INHIBITS CD40 LIGAND EXPRESSION IN T-LYMPHOCYTES
FULEIHAN, R
RAMESH, N
HORNER, A
AHERN, D
BELSHAW, PJ
ALBERG, DG
STAMENKOVIC, I
HARMON, W
GEHA, RS
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03): : 1315 - 1320
[28] Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus.
Sarawar, SR
Lee, BJ
Schoenberger, SP
Reiter, SK
JOURNAL OF LEUKOCYTE BIOLOGY, 2001, : 64 - 64
[29] HIV ENVELOPE GLYCOPROTEIN, ANTIGEN SPECIFIC T-CELL RESPONSES, AND SOLUBLE CD4
MANCA, F
HABESHAW, JA
DALGLEISH, AG
LANCET, 1990, 335 (8693): : 811 - 815
[30] Glycoprotein B Vaccine Is Capable of Boosting Both Antibody and CD4 T-Cell Responses to Cytomegalovirus in Chronically Infected Women
Sabbaj, Steffanie
Pass, Robert F.
Goepfert, Paul A.
Pichon, Sylvie
JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (11): : 1534 - 1541

← 1 2 3 4 5 →