Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

被引：60

作者：

Dong, Lei ^{[1
,2
]}

Zang, Yi ^{[3
]}

Zhou, Dan ^{[1
,2
,3
]}

He, Xiao-Peng ^{[1
,2
]}

Chen, Guo-Rong ^{[1
,2
]}

James, Tony D. ^{[4
]}

Li, Jia ^{[3
]}

机构：

[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China

[4] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 59期

基金：

中国国家自然科学基金;

关键词：

METAL-IONS; RECOGNITIONS; LIGANDS; CELLS;

D O I：

10.1039/c5cc04357c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.

引用

页码：11852 / 11855

页数：4

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