Persulfate promoted tandem radical cyclization of ortho-cyanoarylacrylamides with oxamic acids for construction of carbamoyl quinoline-2,4-diones under metal-free conditions

被引：28
作者：
Han, Qing-Qing [1 ]
Sun, Yuan-Yuan [1 ]
Yang, Shao-Hui [1 ]
Song, Jing-Cheng [1 ]
Wang, Zu-Li [1 ]
机构：
[1] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Ortho-cyanoarylacrylamides; Oxamic acids; Quinoline-2,4-diones; Metal-free; Persulfates; EXTERNAL PHOTOSENSITIZER-FREE; ADDITION/CYCLIZATION CASCADE; ACTIVATED ALKENES; RECENT PROGRESS; SULFINIC ACIDS; N-OXIDES; ACCESS; EFFICIENT; 1,6-ENYNES; OXIDATION;
D O I：
10.1016/j.cclet.2021.04.019
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and practical methods for the synthesis of carbamoyl quinoline-2,4-diones via the reaction of ortho-cyanoarylacrylamides with oxamic acids was described. This cyclic reaction could be performed efficiently under metal free conditions. Various products with functional groups could be obtained with moderate to high yields via radical mechanism. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
引用
收藏
页码：3632 / 3635
页数：4
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