Penicidones A-C, three cytotoxic alkaloidal metabolites of an endophytic Penicillium sp.

被引：61

作者：

Ge, Hui Ming ^{[1
]}

Shen, Yao ^{[1
]}

Zhu, Chun Hua ^{[1
]}

Tan, Shu Hua ^{[1
]}

Ding, Hui ^{[1
]}

Song, Yong Chun ^{[1
]}

Tan, Ren Xiang ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, State Key Lab Pharmaceut Biotechnol, Inst Funct Biomol, Nanjing 210093, Peoples R China

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Penicillium sp; Quercus variabilis; Fagaceae; endophyte; alkaloid; penicidone A; penicidone B; penicidone C; cytotoxicity;

D O I：

10.1016/j.phytochem.2007.07.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Along with the known secondary metabolites lumichrome , physcion, and emodin-1,6-dimethyl ether, three alkaloids named penicidones A-C (1-3) were isolated from the culture of Penicillium sp. IFB-E022, an endophytic fungal strain residing in the stem of Quercus variabilis (Fagaceae). The structures of penicidones A-C were established by a correlative interpretation of spectroscopic data including IR, UV and HR-ESI-MS, as well as by analysis of a set of I D and 2D NMR experiments. The stereochemistry of compounds I and 2 was obtained by comparison of the optical rotation with those of vermistatin and its analogues. Penicidones A-C were the first group of natural products possessing a penicidone framework. Compounds 1-3 exhibited moderate cytotoxicity against four cancer cell lines. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：571 / 576

页数：6

共 24 条

[1] Expression, purification, and characterization of TylB, an aminotransferase involved in the biosynthesis of mycaminose [J].