Leukemic Cells Gas "Up" Leaky Bone Marrow Blood Vessels

被引：2
作者：
Itkin, Tomer [1 ]
Rafii, Shahin [1 ]
机构：
[1] Weill Cornell Med, Ansary Stem Cell Inst, Div Regenerat Med, Dept Med, New York, NY 10065 USA
来源：
CANCER CELL | 2017年 / 32卷 / 03期
关键词：
HEMATOPOIETIC STEM-CELLS; ENDOTHELIAL-CELLS; NICHES;
D O I：
10.1016/j.ccell.2017.08.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Cell, Passaro et al. demonstrate how leukemia through aberrant induction of reactive oxygen species and nitric oxide production trigger marrow vessel leakiness, instigating pro-leukemic function. Disrupted tumor blood vessels promote exhaustion of non-malignant stem and progenitor cells and may facilitate leukemia relapse following chemotherapeutic treatment.
引用
收藏
页码：276 / 278
页数：3
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