Antifungal mechanism of polygodial

The primary antifungal action of polygodial comes in part from its ability to function Bs a nonionic surfactant, disrupting the lipid-protein interface of integral proteins and denaturing their conformation. As a result, the antifungal mechanism of this sesquiterpene dialdehyde is associated with the membrane functions or derangement of the:membrane. For example, the glucose-induced medium acidification process of Saccharomyces cerevisiae was inhibited by polygodial presumably caused by inhibition of the plasma membrane H+-ATPase. However, the potent antifungal activity of polygodial results from its multiple functions.