Severe Cholestatic Hepatitis due to Temozolomide: An Adverse Drug Effect to Keep in Mind. Case Report and Review of Literature

被引：12

作者：

Grieco, Antonio ^{[1
]}

Tafuri, Maria Antonietta ^{[2
]}

Biolato, Marco ^{[1
]}

Diletto, Barbara ^{[2
]}

Di Napoli, Nicola ^{[1
,2
]}

Balducci, Nicola ^{[1
,2
]}

Vecchio, Fabio Maria ^{[3
]}

Miele, Luca

机构：

[1] Univ Cattolica Sacro Cuore, Inst Internal Med, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Inst Radiotherapy, I-00168 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Inst Pathol, I-00168 Rome, Italy

来源：

MEDICINE | 2015年 / 94卷 / 12期

关键词：

ADJUVANT TEMOZOLOMIDE; GLIOBLASTOMA; RADIOTHERAPY; CONCOMITANT; TOXICITY;

D O I：

10.1097/MD.0000000000000476

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Temozolomide is the current standard of therapy for postoperative patients with glioblastoma starting adjuvant radiotherapy. Hematologic adverse events are the most frequent side effects of temozolomide, while liver toxicity has been reported only in the post-marketing period. Here we report a case of severe temozolomide-induced liver injury during concurrent radiotherapy treatment, at a dose level of 75 mg/m(2). The aim of this case report is to focus on the problems of temozolomide-induced hepatotoxicity. In conclusion, a close monitoring of liver function tests is recommended during treatment with temozolomide.

引用

页数：3

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