Two new isoflavones from the seeds of Psoralea corylifolia with diacylglycerol acyltransferase inhibitory activity

被引：3
|
作者：
Wang, Cui-Yun [1 ]
Ai, Guang-Feng [1 ,2 ]
Zhang, Ya-Fei [1 ]
机构：
[1] 1 People's Hosp, Dept Pharm, Jining, Jining, Peoples R China
[2] 1 People's Hosp, Dept Pharm,CONTACT Guang,Feng,Jining, Jining, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 04期
关键词：
Leguminosae; Psoralea corylifolia; isoflavones; diabetes; DGAT; IDENTIFICATION; METABOLITES; FRUITS;
D O I：
10.1080/10286020.2019.1570159
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new compounds 7-hydroxy-4'-methoxy-3'-(7''-hydroxy-3'',7''-dimethyl-octa-2'',5''-dienyl)-isoflavone (1) and 7-hydroxy-4'-methoxy-3'-(6''-hydroxy-3'',7''-dimethyl-octa-2'',7''-dienyl)-isoflavone (2), together with five known compounds (3-7), were isolated from EtOAc-soluble extract of the seeds of Psoralea corylifolia. Their structures were elucidated on the basis of detailed spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against diacylglycerol acyltransferase (DGAT). And compounds 1-7 displayed significant inhibitory activity on DGAT1 with IC50 values ranging from 51.2 +/- 1.1 to 116.4 +/- 1.3 mu M.
引用
收藏
页码：346 / 352
页数：7
相关论文
共 50 条
  • [21] Antibacterial compounds from the seeds of Psoralea corylifolia
    Khatune, NA
    Islam, ME
    Haque, ME
    Khondkar, P
    Rahman, MM
    FITOTERAPIA, 2004, 75 (02) : 228 - 230
  • [22] Aldose Reductase Inhibitory Activity of the Compounds from the Seed of Psoralea corylifolia
    Shim, Sang Hee
    Kim, Yujin
    Lee, Joo Young
    Song, Dae-Geun
    Pan, Cheol-Ho
    Jung, Sang Hoon
    JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, 2009, 52 (05): : 568 - 572
  • [23] Aldose reductase inhibitory activity of the compounds from the seed of Psoralea corylifolia
    Sang Hee Shim
    Yujin Kim
    Joo Young Lee
    Dae-Geun Song
    Cheol-Ho Pan
    Sang Hoon Jung
    Journal of the Korean Society for Applied Biological Chemistry, 2009, 52 : 568 - 572
  • [24] In vitro BACE-1 Inhibitory Phenolic Components from the Seeds of Psoralea corylifolia
    Choi, Yeon Hee
    Yon, Gyu Hwan
    Hong, Kyung Sik
    Yoo, Dae Seok
    Choi, Chun Whan
    Park, Woo-Kyu
    Kong, Jae Yang
    Kim, Young Sup
    Ryu, Shi Yong
    PLANTA MEDICA, 2008, 74 (11) : 1405 - 1408
  • [25] Antitumour active fraction from Psoralea corylifolia seeds
    Latha, PG
    Panikkar, KR
    FITOTERAPIA, 1998, 69 (05) : 451 - 455
  • [26] Isolation of chalkones from the seeds of Psoralea corylifolia Linn
    Agarwal, Deepshikha
    Garg, S. P.
    Sah, Pramilla
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2006, 45 (11): : 2574 - 2579
  • [27] BAKUCHALCONE, A DIHYDROFURANOCHALCONE FROM THE SEEDS OF PSORALEA-CORYLIFOLIA
    GUPTA, GK
    SURI, JL
    GUPTA, BK
    DHAR, KL
    PHYTOCHEMISTRY, 1982, 21 (08) : 2149 - 2151
  • [28] NEW CHROMENOCHALCONE BAVA-CHROMENE FROM SEEDS OF PSORALEA-CORYLIFOLIA
    BAJWA, BS
    SESHADRI, TR
    KHANNA, PL
    CURRENT SCIENCE, 1972, 41 (22): : 814 - &
  • [29] New constituents from Psoralea corylifolia
    Tewari, Amit
    Bhakuni, R. S.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2010, 49 (02): : 256 - 259
  • [30] Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia
    Chen, Chiang-Hsiang
    Hwang, Tsong-Long
    Chen, Li-Chai
    Chang, Tsung-Hsien
    Wei, Chun-Sheng
    Chen, Jih-Jung
    PHYTOCHEMISTRY, 2017, 143 : 186 - 193
12345