Eosinophilic Chronic Obstructive Pulmonary Disease

被引：12

作者：

Weissler, Jonathan C. ^{[1
]}

Adams, Traci N. ^{[1
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Div Pulm & Crit Care Med, Dept Internal Med, 6201 Harry Hines Blvd, Dallas, TX 75390 USA

来源：

LUNG | 2021年 / 199卷 / 06期

关键词：

Eosinophilia; COPD; Exacerbation; Interleukin-5; Corticosteroid; BLOOD EOSINOPHILS; INHALED CORTICOSTEROIDS; PERSISTENT ASTHMA; DOUBLE-BLIND; SECONDARY ANALYSIS; EPITHELIAL-CELLS; MEPOLIZUMAB; SPUTUM; EFFICACY; COPD;

D O I：

10.1007/s00408-021-00492-0

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Recent therapeutic advances in the management of asthma have underscored the importance of eosinophilia and the role of pro-eosinophilic mediators such as IL-5 in asthma. Given that a subset of patients with COPD may display peripheral eosinophilia similar to what is observed in asthma, a number of recent studies have implied that eosinophilic COPD is a distinct entity. This review will seek to contrast the mechanisms of eosinophilia in asthma and COPD, the implications of eosinophilia for disease outcome, and review current data regarding the utility of peripheral blood eosinophilia in the management of COPD patients.

引用

页码：589 / 595

页数：7

共 59 条

[1]

Administration UFaD, 2018, 125526 SBLA ADM UFAD

[2] Blood Eosinophils and Outcomes in Severe Hospitalized Exacerbations of COPD [J].

Bafadhel, Mona ;

Greening, Neil J. ;

Harvey-Dunstan, Theresa C. ;

Williams, Johanna E. A. ;

Morgan, Michael D. ;

Brightling, Christopher E. ;

Hussain, Syed F. ;

Pavord, Ian D. ;

Singh, Sally J. ;

Steiner, Michael C. .

CHEST, 2016, 150 (02) :320-328

[3] Blood eosinophils as a marker of response to inhaled corticosteroids in COPD [J].

Barnes, Neil C. ;

Sharma, Raj ;

Lettis, Sally ;

Calverley, Peter M. A. .

EUROPEAN RESPIRATORY JOURNAL, 2016, 47 (05) :1374-1382

[4] Inflammatory mechanisms in patients with chronic obstructive pulmonary disease [J].

Barnes, Peter J. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 138 (01) :16-27

[5] Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease [J].

Barnes, Peter J. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 131 (03) :636-645

[6] Reduced histone deacetylase in COPD - Clinical implications [J].

Barnes, PJ .

CHEST, 2006, 129 (01) :151-155

[7] Eosinophil counts in first COPD hospitalizations: a comparison of health service utilization [J].

Belanger, Maryse ;

Couillard, Simon ;

Courteau, Josiane ;

Larivee, Pierre ;

Poder, Thomas G. ;

Carrier, Nathalie ;

Girard, Kim ;

Vezina, Felix-Antoine ;

Vanasse, Alain .

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2018, 13 :3045-3054

[8] Peripheral blood eosinophilia and hypersensitivity reactions among patients receiving outpatient parenteral antibiotics [J].

Blumenthal, Kimberly G. ;

Youngster, Ilan ;

Rabideau, Dustin J. ;

Parker, Robert A. ;

Manning, Karen S. ;

Walensky, Rochelle P. ;

Nelson, Sandra B. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 136 (05) :1288-+

[9] Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study [J].

Brightling, Christopher E. ;

Bleecker, Eugene R. ;

Panettieri, Reynold A., Jr. ;

Bafadhel, Mona ;

She, Dewei ;

Ward, Christine K. ;

Xu, Xiao ;

Birrell, Claire ;

van der Merwe, Rene .

LANCET RESPIRATORY MEDICINE, 2014, 2 (11) :891-901

[10] Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease [J].

Byers, Derek E. ;

Alexander-Brett, Jennifer ;

Patel, Anand C. ;

Agapov, Eugene ;

Dang-Vu, Geoffrey ;

Jin, Xiaohua ;

Wu, Kangyun ;

You, Yingjian ;

Alevy, Yael ;

Girard, Jean-Philippe ;

Stappenbeck, Thaddeus S. ;

Patterson, G. Alexander ;

Pierce, Richard A. ;

Brody, Steven L. ;

Holtzman, Michael J. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (09) :3967-3982

← 1 2 3 4 5 6 →