Influence of mulberry leaf extract on serum adiponectin, visfatin and lipid profile levels in type 2 diabetic rats

The effect of ethanolic mulberry leaf extract (MLE) and mulberry leaf powder (MLP) on glycemic control, serum adiponectin, visfatin and lipid profile in type2 diabetic rats have been investigated. 30 male wistar rats randomly divided into 5 groups. One group was randomly assigned as control (I) and diabetes was induced in others by administration of streptozotocin (STZ) (55 mg/kg body weight) 15 minutes after the administration of nicotinamide (110 mg/kg body weight) intraperitoneally. Finally, fasting blood glucose (FBG), lipid profile, adiponectin and visfatin were assessed after 6 weeks. Lipid profiles including serum FBG, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-c), very low-density lipoprotein cholesterol (VLDL) and visfatin significantly decreased and high-density lipoprotein cholesterol (HDL-c) and adiponectin increased in the two groups of treated diabetic rats in comparison to the diabetic control (p<0.05). For all the investigated factors, there was no significant difference between two treatment methods. However, MLP was more effective than MLE in improving visfatin. Results showed that MLE and MLP possess hypoglycemic and hypolipidemic activities and play an important role in regulating the secretion of adipokines such as adiponectin and visfatin.