Acute Intrathecal Baclofen Withdrawal: A Brief Review of Treatment Options

被引：54
作者：
Ross, James C. [3 ]
Cook, Aaron M. [1 ,2 ]
Stewart, Gary L. [4 ]
Fahy, Brenda G. [4 ,5 ]
机构：
[1] Univ Kentucky, Coll Pharm, Dept Pharm Practice & Sci, Lexington, KY 40536 USA
[2] UKHealthcare, Serv Pharm, Lexington, KY 40536 USA
[3] St Joseph Hlth Syst, Dept Pharm, Lexington, KY 40504 USA
[4] UKHealthcare, Dept Anesthesiol, Lexington, KY 40536 USA
[5] UKHealthcare, Dept Neurosurg, Lexington, KY 40536 USA
来源：
NEUROCRITICAL CARE | 2011年 / 14卷 / 01期
关键词：
Baclofen; Intrathecal; Withdrawal; Seizure; Tizanidine; ABRUPT WITHDRAWAL; CEREBRAL-PALSY; PUMP CATHETER; SPINAL-CORD; MANAGEMENT; INFUSION; CYPROHEPTADINE; OVERDOSE;
D O I：
10.1007/s12028-010-9422-6
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Acute baclofen toxicity and withdrawal can present with a constellation of symptoms making differentiation between these two entities and other potential diagnoses challenging. Baclofen withdrawal is associated with numerous complications which may require neurocritical care expertise such as respiratory failure, refractory seizures, delirium, and blood pressure lability. Case report and literature review. This case report discusses a case of intrathecal baclofen (ITB) withdrawal, focusing on the differential diagnosis for acute baclofen withdrawal and reviews the various options that exist to treat the symptoms of acute baclofen withdrawal such as benzodiazepines, propofol, skeletal muscle relaxants, and tizanidine. Critical care practitioners should be prepared to treat this potentially devastating and often refractory complication of ITB therapy.
引用
收藏
页码：103 / 108
页数：6
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