β-cyclodextrin- soy soluble polysaccharide based core-shell bionanocomposites hydrogel for vitamin E swelling controlled delivery

Hydrogel nanocomposites (HGNCs), with a hydrophobic inner hollows structure and a hydrophilic exterior, is often used to encapsulate the broadest range of guest molecules. Herein, we established a three-dimensional, nanocomposites, superabsorbent, malleable, and bioadhesive HGNCs via chemical crosslinker poly (ethylene glycol) diglycidyl ether (PEGDGE) to enhance the controlled release and bioavailability of Vitamin E (VE). beta-cyclodextrin (beta-CD) are integrated as multi-core units in the soy soluble polysaccharide (SSPS) polymer network in which the beta-CD cavities act as carriers for (VE) by host-guest interaction. We have examined the detailed structures and morphology by FTIR, DSC, XRD, SEM, TEM, AFM, and CLSM. Overall, increasing the beta-CD than SSPS in the reaction mixture (from 10 to 25%) led to enhance the crosslinking degree, improve the elastic behavior (G'>G ''), increase the particle size (from 114.2 to 202.9 nm), and the hardness. Besides, decreasing the adhesiveness, pore size, and swelling. Our (HGNCs) did not rupture under compression up to 90% strain with (1.8 MPa) strength. The nanocomposites (1:1) exhibited less nanosized after pectinase and a-amylase hydrolysis (75 and 124 nm, respectively). Also, the (HGNCs) exhibited outstanding swelling-adsorption and sustained release (over 230 h) towards VE in vitro. It showed high encapsulation efficiency and loading capacity (79.10 and 16.04%, respectively). Additionally, the oral administration of VE-loaded HGNCs in rats resulted in a sustained increase of plasma VE levels over 12 h post-administration. The relative pharmacological bioavailability of VE was larger for VE-loaded HGNCs (reached to 7.5-fold increase) compared to free VE suspension. Keywords: Nanohydrogel; beta-cyclodextrin; Soy soluble polysaccharide; Vitamin E; swelling; control release.