Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1)

被引：1

作者：

Wågsäter, D ^{[1
]}

Sirsjö, A

Dimberg, J

机构：

[1] Univ Orebro, Dept Caring Sci, Div Biomed, S-70182 Orebro, Sweden

[2] Sch Hlth Sci, Dept Nat Sci & Biomed, Jonkoping, Sweden

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2003年 / 22卷 / 03期

关键词：

Id2; all-trans retinoic acid; THP-1; cells; differentiation; proliferation; helix-loop-helix;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Accumulated evidence supports that both Id helix-loop-helix proteins and derivatives of vitamin A, retinoids, play a pivotal role in the regulation of cell growth and differentiation. We analyzed the effects of all-trans retinoic acid (atRA) on the gene and protein expression of Id2 in THP-1 cells and found a suppression of the levels of Id2. The down-regulation was abolished towards a constitutively expressed level of Id2 mRNA. The decreased level of Id2 was associated with growth suppression and does support the prevalent conception of the action of Id2 as a stimulator of cell growth.

引用

页码：471 / 475

页数：5

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