Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1)

被引:1
作者
Wågsäter, D [1 ]
Sirsjö, A
Dimberg, J
机构
[1] Univ Orebro, Dept Caring Sci, Div Biomed, S-70182 Orebro, Sweden
[2] Sch Hlth Sci, Dept Nat Sci & Biomed, Jonkoping, Sweden
关键词
Id2; all-trans retinoic acid; THP-1; cells; differentiation; proliferation; helix-loop-helix;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Accumulated evidence supports that both Id helix-loop-helix proteins and derivatives of vitamin A, retinoids, play a pivotal role in the regulation of cell growth and differentiation. We analyzed the effects of all-trans retinoic acid (atRA) on the gene and protein expression of Id2 in THP-1 cells and found a suppression of the levels of Id2. The down-regulation was abolished towards a constitutively expressed level of Id2 mRNA. The decreased level of Id2 was associated with growth suppression and does support the prevalent conception of the action of Id2 as a stimulator of cell growth.
引用
收藏
页码:471 / 475
页数:5
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