Rh(III)-catalyzed C-H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines

被引：35
|
作者：
Chen, Renjie [1 ]
Qi, Jifeng [1 ]
Mao, Zhenjun [1 ]
Cui, Sunliang [1 ]
机构：
[1] Zhejiang Univ, Inst Drug Discovery & Design, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 26期
基金：
中国国家自然科学基金;
关键词：
N BOND FORMATION; BETA-PHENYLETHYLAMINES; INTERNAL ALKYNES; FACILE SYNTHESIS; ACTIVATION; ACCESS; ACIDS; ANNULATION; BENZAMIDES; ALKALOIDS;
D O I：
10.1039/c6ob00942e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Rh(III)-catalyzed C-H activation/cyclization of oximes and alkenes for facile and regioselective access to isoquinolines has been developed. This protocol features mild reaction conditions and easily accessible starting materials, and has been applied to the concise synthesis of moxaverine. A kinetic isotope effect study was conducted and a plausible mechanism was proposed.
引用
收藏
页码：6201 / 6204
页数：4
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