mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

被引：123

作者：

Gagne, Matthew ^{[1
]}

Moliva, Juan, I ^{[1
]}

Foulds, Kathryn E. ^{[1
]}

Andrew, Shayne F. ^{[1
]}

Flynn, Barbara J. ^{[1
]}

Werner, Anne P. ^{[1
]}

Wagner, Danielle A. ^{[1
]}

Teng, I-Ting ^{[1
]}

Lin, Bob C. ^{[1
]}

Moore, Christopher ^{[1
]}

Jean-Baptiste, Nazaire ^{[1
]}

Carroll, Robin ^{[1
]}

Foster, Stephanie L. ^{[2
]}

Patel, Mit ^{[2
]}

Ellis, Madison ^{[2
]}

Edara, Venkata-Viswanadh ^{[2
]}

Maldonado, Nahara Vargas ^{[2
]}

Minai, Mahnaz ^{[3
]}

McCormick, Lauren ^{[1
]}

Honeycutt, Christopher Cole ^{[1
]}

Nagata, Bianca M. ^{[3
]}

Bock, Kevin W. ^{[3
]}

Dulan, Caitlyn N. M. ^{[1
]}

Cordon, Jamilet ^{[1
]}

Flebbe, Dillon R. ^{[1
]}

Todd, John-Paul M. ^{[1
]}

McCarthy, Elizabeth ^{[1
]}

Pessaint, Laurent ^{[4
]}

Van Ry, Alex ^{[4
]}

Narvaez, Brandon ^{[4
]}

Valentin, Daniel ^{[4
]}

Cook, Anthony ^{[4
]}

Dodson, Alan ^{[4
]}

Steingrebe, Katelyn ^{[4
]}

Nurmukhambetova, Saule T. ^{[1
]}

Godbole, Sucheta ^{[1
]}

Henry, Amy R. ^{[1
]}

Laboune, Farida ^{[1
]}

Roberts-Torres, Jesmine ^{[1
]}

Lorang, Cynthia G. ^{[1
]}

Amin, Shivani ^{[1
]}

Trost, Jessica ^{[1
]}

Naisan, Mursal ^{[1
]}

Basappa, Manjula ^{[1
]}

Willis, Jacquelyn ^{[1
]}

Wang, Lingshu ^{[1
]}

Shi, Wei ^{[1
]}

Doria-Rose, Nicole A. ^{[1
]}

Zhang, Yi ^{[1
]}

Yang, Eun Sung ^{[1
]}

机构：

[1] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

[2] Emory Univ, Emory Vaccine Ctr, Yerkes Natl Primate Res Ctr, Dept Pediat,Sch Med, Atlanta, GA 30322 USA

[3] NIAID, Infect Dis Pathogenesis Sect, Comparat Med Branch, NIH, Rockville, MD 20892 USA

[4] Bioqual Inc, Rockville, MD 20850 USA

[5] Moderna Inc, Cambridge, MA 02139 USA

[6] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[7] NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20892 USA

[8] Emory Univ, Yerkes Natl Primate Res Ctr, Div Pathol, Sch Med, Atlanta, GA 30329 USA

来源：

CELL | 2022年 / 185卷 / 09期

基金：

美国国家卫生研究院;

关键词：

INFLUENZA; VARIANT; SPIKE; INFECTION; BCL6;

D O I：

10.1016/j.cell.2022.03.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to neutralization following immunization with ancestral spike-matched vaccines. It is unclear whether boosting with Omicron-matched vaccines would enhance protection. Here, nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at week 41 with mRNA-1273 or mRNA-Omicron. Neutralizing titers against D614G were 4,760 and 270 reciprocal ID 50 at week 6 (peak) and week 41 (preboost), respectively, and 320 and 110 for Omicron. 2 weeks after the boost, titers against D614G and Omicron increased to 5,360 and 2,980 for mRNA-1273 boost and 2,670 and 1,930 for mRNA-Omicron, respectively. Similar increases against BA.2 were observed. Following either boost, 70%-80% of spike-specific B cells were cross-reactive against WA1 and Omicron. Equivalent control of virus replication in lower airways was observed following Omicron challenge 1 month after either boost. These data show that mRNA-1273 and mRNA-Omicron elicit comparable immunity and protection shortly after the boost.

引用

页码：1556 / +

页数：34

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