Hypertension in Obesity: Novel Insights

被引:45
作者
Natsis, Michail [1 ]
Antza, Christina [1 ]
Doundoulakis, Ioannis [1 ]
Stabouli, Stella [2 ]
Kotsis, Vasilios [1 ]
机构
[1] Aristotle Univ Thessaloniki, Papageorgiou Hosp, Dept Internal Med 3, Hypertens ABPM ESH Ctr Excellence 24h, Thessaloniki, Greece
[2] Hippokrateion Hosp, Dept Pediat 1, Thessaloniki, Greece
关键词
Obesity; hypertension; antiobesity drugs; obesity-induced hypertension; treatment; weight loss; BODY-MASS-INDEX; AMBULATORY BLOOD-PRESSURE; CONTROLLED-RELEASE PHENTERMINE/TOPIRAMATE; TYPE-2; DIABETES-MELLITUS; GLP-1 RECEPTOR AGONISTS; CORONARY-HEART-DISEASE; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; MASKED HYPERTENSION; INSULIN-RESISTANCE;
D O I
10.2174/1573402115666190415154603
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background: The relationship between obesity and hypertension has been established in both adults and children. The combination of obesity, hypertension and other cardiovascular risk factors significantly increases the likelihood of adverse cardiovascular effects and raises concerns about aggressive treatment strategies. Objective: Despite the impressive elements which indicate an important role for excessive weight gain in increasing blood pressure, not all obese patients are hypertensive. A subgroup of obese people may not develop hypertension. Furthermore, masked hypertension occurs more common among obese patients, and body fat distribution has a major role in the development of hypertension. Method: We conducted a research of the relevant literature regarding obesity-induced hypertension and possible treatment strategies. Results: Successful weight loss is correlated with blood pressure reduction and requires a multidisciplinary approach that includes personalized dietary interventions combined with regular exercise and cognitive behavioral therapy. Conclusion: Pharmacological therapy may be considered as part of a comprehensive obesity management strategy. More research and new treatment therapies are required in this field.
引用
收藏
页码:30 / 36
页数:7
相关论文
共 94 条
[1]   Controlled-Release Phentermine/Topiramate in Severely Obese Adults: A Randomized Controlled Trial (EQUIP) [J].
Allison, David B. ;
Gadde, Kishore M. ;
Garvey, William Timothy ;
Peterson, Craig A. ;
Schwiers, Michael L. ;
Najarian, Thomas ;
Tam, Peter Y. ;
Troupin, Barbara ;
Day, Wesley W. .
OBESITY, 2012, 20 (02) :330-342
[2]   Early Vascular Aging Risk Assessment From Ambulatory Blood Pressure Monitoring: The Early Vascular Aging Ambulatory Score [J].
Antza, Christina ;
Doundoulakis, Ioannis ;
Akrivos, Evagelos ;
Stabouli, Stella ;
Trakatelli, Christina ;
Doumas, Michael ;
Kotsis, Vasilios .
AMERICAN JOURNAL OF HYPERTENSION, 2018, 31 (11) :1197-1204
[3]   Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance [J].
Aroor, Annayya R. ;
McKarns, Susan ;
DeMarco, Vincent G. ;
Jia, Guanghong ;
Sowers, James R. .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2013, 62 (11) :1543-1552
[4]  
Ayyad C, 2000, Obes Rev, V1, P113, DOI 10.1046/j.1467-789x.2000.00019.x
[5]   White-coat UnControlled Hypertension, Masked UnControlled Hypertension, and True UnControlled Hypertension, phonetic and mnemonic terms for treated hypertension phenotypes [J].
Banegas, Jose R. ;
Ruilope, Luis M. ;
Williams, Bryan .
JOURNAL OF HYPERTENSION, 2018, 36 (02) :446-447
[6]   The Natural Course of Healthy Obesity Over 20 Years [J].
Bell, Joshua A. ;
Hamer, Mark ;
Sabia, Severine ;
Singh-Manoux, Archana ;
Batty, G. David ;
Kivimaki, Mika .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 65 (01) :101-102
[7]   Naltrexone/bupropion for obesity: An investigational combination pharmacotherapy for weight loss [J].
Billes, Sonja K. ;
Sinnayah, Puspha ;
Cowley, Michael A. .
PHARMACOLOGICAL RESEARCH, 2014, 84 :1-11
[8]  
Boillot A, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0052708, 10.1371/journal.pone.0064417]
[9]   Lorcaserin: A novel antiobesity drug [J].
Brashier, Dick B. S. ;
Sharma, A. K. ;
Dahiya, Navdeep ;
Singh, S. K. ;
Khadka, Anjan .
JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS, 2014, 5 (02) :175-178
[10]   Medical treatment of obesity: The past, the present and the future [J].
Bray, George A. .
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2014, 28 (04) :665-684