Optimizing the high-field relaxivity by self-assembling of macrocyclic Gd(III) complexes

被引：8
|
作者：
Lawson, Dale [1 ,3 ]
Barge, Alessandro [2 ]
Terreno, Enzo [1 ]
Parker, David [3 ]
Aime, Silvio [1 ]
Botta, Mauro [4 ]
机构：
[1] Univ Turin, Mol Imaging Ctr, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy
[2] Univ Turin, Dept Drug Sci & Technol, I-10125 Turin, Italy
[3] Univ Durham, Dept Chem, Durham DH1 3LE, England
[4] Univ Piemonte Orientale, Dipartimento Sci & Innovaz Tecnol, I-15121 Alessandria, Italy
来源：
DALTON TRANSACTIONS | 2015年 / 44卷 / 11期
基金：
英国工程与自然科学研究理事会;
关键词：
MRI-CONTRAST AGENTS; GADOLINIUM COMPLEXES; WATER EXCHANGE; AQUEOUS-SOLUTION; ANION-BINDING; GD; LUMINESCENCE; SELECTIVITY; OPTIMIZATION; EUROPIUM;
D O I：
10.1039/c4dt02971b
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Using recognition moieties that bind to the inner co-ordination sphere of a monomeric DO3A-type diaqua complex, dimeric poly(aminocarboxylate) gadolinium(III) compounds can be formed with greatly enhanced relaxivities, arising from optimized contributions of inner-and second spheres of hydration.
引用
收藏
页码：4910 / 4917
页数：8
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