Optimizing the high-field relaxivity by self-assembling of macrocyclic Gd(III) complexes

被引：8

作者：

Lawson, Dale ^{[1
,3
]}

Barge, Alessandro ^{[2
]}

Terreno, Enzo ^{[1
]}

Parker, David ^{[3
]}

Aime, Silvio ^{[1
]}

Botta, Mauro ^{[4
]}

机构：

[1] Univ Turin, Mol Imaging Ctr, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy

[2] Univ Turin, Dept Drug Sci & Technol, I-10125 Turin, Italy

[3] Univ Durham, Dept Chem, Durham DH1 3LE, England

[4] Univ Piemonte Orientale, Dipartimento Sci & Innovaz Tecnol, I-15121 Alessandria, Italy

来源：

DALTON TRANSACTIONS | 2015年 / 44卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

MRI-CONTRAST AGENTS; GADOLINIUM COMPLEXES; WATER EXCHANGE; AQUEOUS-SOLUTION; ANION-BINDING; GD; LUMINESCENCE; SELECTIVITY; OPTIMIZATION; EUROPIUM;

D O I：

10.1039/c4dt02971b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Using recognition moieties that bind to the inner co-ordination sphere of a monomeric DO3A-type diaqua complex, dimeric poly(aminocarboxylate) gadolinium(III) compounds can be formed with greatly enhanced relaxivities, arising from optimized contributions of inner-and second spheres of hydration.

引用

页码：4910 / 4917

页数：8

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