A non-canonical Grb2-PLC-γ1-Sos cascade triggered by lipovitellin 1, an apolipoprotein B homologue

被引：6
作者：
Browaeys-Poly, Edith
Broutin, Isabelle
Antoine, Anne-Frederique
Marin, Matthieu
Lescuyer, Arlette
Vilain, Jean Pierre
Ducruix, Arnaud
Cailliau, Katia
机构：
[1] Univ Sci & Tech Lille Flandres Artois, IFR 147, EA 4020, Lab Regulat Signaux Div, F-59655 Villeneuve Dascq, France
[2] Univ Paris 05, CNRS, Fac Pharm, UMR 8015,Lab Cristallograph & RMN Biol, F-75270 Paris, France
来源：
CELLULAR SIGNALLING | 2007年 / 19卷 / 12期
关键词：
Grb2; PLC-gamma; 1; Sos; lipovitellin; G2/M transition;
D O I：
10.1016/j.cellsig.2007.08.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The injection of the Grb2 adapter in Xenopus oocytes promotes G2/M transition without stimulation from a receptor only the first day after the oocytes removal from the ovaries. This cell cycle reinitiation is Ras-dependent and requires the SH2 and SH3 domains of Grb2. The SH2 domain of Grb2 binds the tyrosine phosphorylated lipovitellin1, a homologue of the human apolipoprotein B. The N-SH3 domain of Grb2 is linked to a proline-rich sequence of the C2 domain of PLC-gamma 1, PLC-gamma 1 itself is linked, through its SH3 domain, to the C-terminal proline-rich region of Sos. When Grb2-PLC-gamma 1-Sos is associated, PLC-gamma 1 is not phosphotylated on Y783 but shows a phospholipase activity. Inhibition of lipovitellin 1 or PLC-gamma 1 avoids Grb2-induced cell cycle reinitiation. Therefore, the Grb2-lipovitellin 1 association is the starting point of a novel signaling pathway, where PLC-gamma 1 binds Grb2 and recruits Sos. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：2540 / 2548
页数：9
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