Increased Fos induction in adult rats that experienced neonatal peripheral inflammation

被引：30

作者：

Tachibana, T ^{[1
]}

Ling, QD ^{[1
]}

Ruda, MA ^{[1
]}

机构：

[1] NIDCR, Cellular Neurosci Sect, Pain & Neurosensory Mech Branch, NIH, Bethesda, MD 20892 USA

来源：

NEUROREPORT | 2001年 / 12卷 / 05期

关键词：

c-fos; development; Fos; inflammation; neonate; pain; spinal cord;

D O I：

10.1097/00001756-200104170-00012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The response to noxious stimulation was compared in adult rats that had peripheral inflammation as neonates and untreated rats. On postnatal day 1, rat pups experienced complete Freund's adjuvant (CFA)-induced inflammation of the left hind paw. At 8 weeks of age, these rats and neonatal untreated rats received a bilateral injection of CFA into their hind paws. Fos-like immunoreactivity (Fos-LI) was used as a measure of neuronal activity in dorsal horn nociceptive pathways. A significant increase in Fos-LI was found on the left side of the lumbar spinal cord of neonatal treated rats as compared to neonatal untreated rats. These results suggest that the experience of neonatal peripheral inflammation may result in an increase in the response of spinal cord neurons to peripheral inflammation as adults. NeuroReport 12:925-927 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：925 / 927

页数：3

共 21 条

[1]

ANAND KJS, 1993, PAIN NEONATES, P1

[2] EXPRESSION OF C-FOS-LIKE PROTEIN AS A MARKER FOR NEURONAL-ACTIVITY FOLLOWING NOXIOUS-STIMULATION IN THE RAT [J].

BULLITT, E .

JOURNAL OF COMPARATIVE NEUROLOGY, 1990, 296 (04) :517-530

[3] PAIN IN THE PRETERM NEONATE - BEHAVIORAL AND PHYSIOLOGICAL INDEXES [J].

CRAIG, KD ;

WHITFIELD, MF ;

GRUNAU, RVE ;

LINTON, J ;

HADJISTAVROPOULOS, HD .

PAIN, 1993, 52 (03) :287-299

[4] SPINAL NEURONS EXHIBITING A SPECIFIC NOCICEPTIVE RESPONSE RECEIVE ABUNDANT SUBSTANCE-P-CONTAINING SYNAPTIC CONTACTS [J].

DE KONINCK, Y ;

RIBEIRODASILVA, A ;

HENRY, JL ;

CUELLO, AC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (11) :5073-5077

[5] Substance P receptor (neurokinin-1)-expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: A c-Fos study in rat [J].

Doyle, CA ;

Hunt, SP .

NEUROSCIENCE, 1999, 89 (01) :17-28

[6] DEVELOPMENTAL BIOLOGY OF INFLAMMATORY PAIN [J].

FITZGERALD, M .

BRITISH JOURNAL OF ANAESTHESIA, 1995, 75 (02) :177-185

[7] CUTANEOUS HYPERSENSITIVITY FOLLOWING PERIPHERAL TISSUE-DAMAGE IN NEWBORN-INFANTS AND ITS REVERSAL WITH TOPICAL ANESTHESIA [J].

FITZGERALD, M ;

MILLARD, C ;

MCINTOSH, N .

PAIN, 1989, 39 (01) :31-36

[8] PAIN SENSITIVITY AND TEMPERAMENT IN EXTREMELY LOW-BIRTH-WEIGHT PREMATURE TODDLERS AND PRETERM AND FULL-TERM CONTROLS [J].

GRUNAU, RVE ;

WHITFIELD, MF ;

PETRIE, JH .

PAIN, 1994, 58 (03) :341-346

[9] INDUCTION OF C-FOS-LIKE PROTEIN IN SPINAL-CORD NEURONS FOLLOWING SENSORY STIMULATION [J].

HUNT, SP ;

PINI, A ;

EVAN, G .

NATURE, 1987, 328 (6131) :632-634

[10] SYNAPTIC RELATIONSHIP BETWEEN SUBSTANCE-P AND THE SUBSTANCE-P RECEPTOR - LIGHT AND ELECTRON-MICROSCOPIC CHARACTERIZATION OF THE MISMATCH BETWEEN NEUROPEPTIDES AND THEIR RECEPTORS [J].

LIU, HT ;

BROWN, JL ;

JASMIN, L ;

MAGGIO, JE ;

VIGNA, SR ;

MANTYH, PW ;

BASBAUM, AI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (03) :1009-1013

← 1 2 3 →