Toll-like receptor ligands energize peptide vaccines through multiple paths

被引：48

作者：

Celis, Esteban

机构：

[1] Univ S Florida, H Lee Moffit Canc Ctr & Res Inst, Program Immunol, Tampa, FL 33612 USA

[2] Univ S Florida, H Lee Moffit Canc Ctr & Res Inst, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA

来源：

CANCER RESEARCH | 2007年 / 67卷 / 17期

关键词：

D O I：

10.1158/0008-5472.CAN-07-1652

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The potential of vaccines for cancer therapy or prevention has vet to be realized. Recently, we showed that using an immunologic adjuvant composed of a Toll-like receptor (TLR) ligand can increase the production of antitumor CTLs produced by a peptide vaccine in a mouse model of breast cancer. By increasing the cross talk between the innate and adaptive immune systems, TLR ligands can drive expansion and memory of CTLs that can destroy cancer cells.

引用

收藏

页码：7945 / 7947

页数：3

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