Toll-like receptor ligands energize peptide vaccines through multiple paths

被引：48
作者：
Celis, Esteban
机构：
[1] Univ S Florida, H Lee Moffit Canc Ctr & Res Inst, Program Immunol, Tampa, FL 33612 USA
[2] Univ S Florida, H Lee Moffit Canc Ctr & Res Inst, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA
来源：
CANCER RESEARCH | 2007年 / 67卷 / 17期
关键词：
D O I：
10.1158/0008-5472.CAN-07-1652
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The potential of vaccines for cancer therapy or prevention has vet to be realized. Recently, we showed that using an immunologic adjuvant composed of a Toll-like receptor (TLR) ligand can increase the production of antitumor CTLs produced by a peptide vaccine in a mouse model of breast cancer. By increasing the cross talk between the innate and adaptive immune systems, TLR ligands can drive expansion and memory of CTLs that can destroy cancer cells.
引用
收藏
页码：7945 / 7947
页数：3
相关论文
共 20 条
  • [1] Challenges in the development of effective peptide vaccines for cancer
    Buteau, C
    Markovic, SN
    Celis, E
    [J]. MAYO CLINIC PROCEEDINGS, 2002, 77 (04) : 339 - 349
  • [2] Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity
    Davila, E
    Celis, E
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (01) : 539 - 547
  • [3] Creating space: an antigen-independent, CpG-induced peripheral expansion of naive and memory T lymphocytes in a full T-cell compartment
    Davila, E
    Velez, MG
    Heppelmann, CJ
    Celis, E
    [J]. BLOOD, 2002, 100 (07) : 2537 - 2545
  • [4] INVIVO PRIMING OF VIRUS-SPECIFIC CYTO-TOXIC LYMPHOCYTES-T WITH SYNTHETIC LIPOPEPTIDE VACCINE
    DERES, K
    SCHILD, H
    WIESMULLER, KH
    JUNG, G
    RAMMENSEE, HG
    [J]. NATURE, 1989, 342 (6249) : 561 - 564
  • [5] The new B7s: Playing a pivotal role in tumor immunity
    Flies, Dallas B.
    Chen, Lieping
    [J]. JOURNAL OF IMMUNOTHERAPY, 2007, 30 (03) : 251 - 260
  • [6] The terminology issue for myeloid-derived suppressor cells
    Gabrilovich, Dmitry I.
    Bronte, Vincenzo
    Chen, Shu-Hsia
    Colombo, Mario P.
    Ochoa, Augusto
    Ostrand-Rosenberg, Suzanne
    Schreiber, Hans
    [J]. CANCER RESEARCH, 2007, 67 (01) : 425 - 425
  • [7] CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
    Janssen, EM
    Lemmens, EE
    Wolfe, T
    Christen, U
    von Herrath, MG
    Schoenberger, SP
    [J]. NATURE, 2003, 421 (6925) : 852 - 856
  • [8] CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
    Janssen, EM
    Droin, NM
    Lemmens, EE
    Pinkoski, MJ
    Bensinger, SJ
    Ehst, BD
    Griffith, TS
    Green, DR
    Schoenberger, SP
    [J]. NATURE, 2005, 434 (7029) : 88 - 93
  • [9] Toll-like receptors as adjuvant receptors
    Kaisho, T
    Akira, S
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2002, 1589 (01): : 1 - 13
  • [10] Immunologically active autoantigens: The role of Toll-like receptors in the development of chronic inflammatory disease
    Marshak-Rothstein, Ann
    Rifkin, Ian R.
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 : 419 - 441
12