Cytotoxic diterpenoids from the roots of Euphorbia stracheyi

被引：13

作者：

Ye, Ye ^{[1
,2
]}

Liu, Guang-Hui ^{[1
,2
]}

Dawa, Drolma ^{[3
]}

Ding, Li-Sheng ^{[1
]}

Cao, Zhi-Xing ^{[4
]}

Zhou, Yan ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Tibet Autonomous Reg Inst Food & Drug Control, Lhasa 850000, Peoples R China

[4] Chengdu Univ Tradit Chinese Med, Pharm Coll, Chengdu 611137, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2020年 / 36卷

基金：

中国国家自然科学基金;

关键词：

Euphorbia stracheyi; Diterpenoid; Cytotoxicity;

D O I：

10.1016/j.phytol.2020.03.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new diterpenoids, euphstrachenols A-C (1, 2, and 11), together with nineteen known analogues were isolated from the roots of Euphorbia stracheyi. Compounds 1 and 2 were lathyrane-type diterpenoids with a decadienoyl acidic moiety. Compound 11 was an ingenane-type diterpenoid with a deca-2 '' E,4 '' E,6 '' E-trien-1-one moiety. Their structures were elucidated by comprehensive spectroscopic analyses. All the isolated compounds were evaluated in vitro for their cytotoxic activity against four human cancer cell lines and a murine cell line, and compounds 1, 2, 4, 5, 7, 9, and 11-14 exhibited moderate cytotoxicity against MV4-11 cell line with IC50 values from 3.48 to 30.02 mu M.

引用

页码：183 / 187

页数：5

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