Cytotoxic diterpenoids from the roots of Euphorbia stracheyi

被引：13
作者：
Ye, Ye [1 ,2 ]
Liu, Guang-Hui [1 ,2 ]
Dawa, Drolma [3 ]
Ding, Li-Sheng [1 ]
Cao, Zhi-Xing [4 ]
Zhou, Yan [1 ]
机构：
[1] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Tibet Autonomous Reg Inst Food & Drug Control, Lhasa 850000, Peoples R China
[4] Chengdu Univ Tradit Chinese Med, Pharm Coll, Chengdu 611137, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2020年 / 36卷
基金：
中国国家自然科学基金;
关键词：
Euphorbia stracheyi; Diterpenoid; Cytotoxicity;
D O I：
10.1016/j.phytol.2020.03.002
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new diterpenoids, euphstrachenols A-C (1, 2, and 11), together with nineteen known analogues were isolated from the roots of Euphorbia stracheyi. Compounds 1 and 2 were lathyrane-type diterpenoids with a decadienoyl acidic moiety. Compound 11 was an ingenane-type diterpenoid with a deca-2 '' E,4 '' E,6 '' E-trien-1-one moiety. Their structures were elucidated by comprehensive spectroscopic analyses. All the isolated compounds were evaluated in vitro for their cytotoxic activity against four human cancer cell lines and a murine cell line, and compounds 1, 2, 4, 5, 7, 9, and 11-14 exhibited moderate cytotoxicity against MV4-11 cell line with IC50 values from 3.48 to 30.02 mu M.
引用
收藏
页码：183 / 187
页数：5
相关论文
共 23 条
  • [1] Identification of new diterpenoids from Euphorbia calyptrata cell cultures
    CrespiPerellino, N
    Garofano, L
    Arlandini, E
    Pinciroli, V
    Minghetti, A
    Vincieri, FF
    Danieli, B
    [J]. JOURNAL OF NATURAL PRODUCTS, 1996, 59 (08): : 773 - 776
  • [2] Global medicinal uses of Euphorbia L. (Euphorbiaceae)
    Ernst, Madeleine
    Grace, Olwen M.
    Saslis-Lagoudakis, C. Haris
    Nilsson, Niclas
    Simonsen, Henrik Toft
    Ronsted, Nina
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2015, 176 : 90 - 101
  • [3] Jatrophane and lathyrane diterpenoids from Euphorbia hyberna L.
    Ferreira, AMVD
    Carvalho, LHM
    Carvalho, MJM
    Sequeira, MM
    Silva, AMS
    [J]. PHYTOCHEMISTRY, 2002, 61 (04) : 373 - 377
  • [4] Flora of China Editorial Committee Chinese Academy of Sciences, 2004, FLORA REIPUBLICAE PO
  • [5] Jatrophane Diterpenoids from Euphorbia glomerulans
    Hasan, Aobulikasimu
    Liu, Ge-Yu
    Hu, Rui
    Aisa, H. A.
    [J]. JOURNAL OF NATURAL PRODUCTS, 2019, 82 (04): : 724 - 734
  • [6] Eight New Diterpenoids from the Roots of Euphorbia nematoopha
    He, Fei
    Pu, Jian-Xin
    Huang, Sheng-Xiong
    Xiao, Wei-Lie
    Yang, Li-Bin
    Li, Xiao-Nian
    Zhao, Yong
    Ding, Jian
    Xu, Cheng-Hui
    Sun, Han-Dong
    [J]. HELVETICA CHIMICA ACTA, 2008, 91 (11) : 2139 - 2147
  • [7] Macrocyclic diterpene polyesters of the jatrophane type from Euphorbia esula
    Hohmann, J
    Vasas, A
    Gunther, G
    Methe, I
    Evanics, F
    Dombi, G
    Jerkovich, G
    [J]. JOURNAL OF NATURAL PRODUCTS, 1997, 60 (04): : 331 - 335
  • [8] Diterpenes from Euphorbia segetalis
    Jakupovic, J
    Jeske, F
    Morgenstern, T
    Tsichritzis, F
    Marco, JA
    Berendsohn, W
    [J]. PHYTOCHEMISTRY, 1998, 47 (08) : 1583 - 1600
  • [9] CHEMISTRY OF FIJIAN PLANTS .4. ENT-ATISANE DITERPENES FROM EUPHORBIA-FIDJIANA
    LAL, AR
    CAMBIE, RC
    RUTLEDGE, PS
    WOODGATE, PD
    [J]. PHYTOCHEMISTRY, 1990, 29 (06) : 1925 - 1935
  • [10] Diterpenes and phloracetophenones from Euphorbia portulacoides
    Morgenstern, T
    Bittner, M
    Silva, M
    Aqueveque, P
    Jakupovic, J
    [J]. PHYTOCHEMISTRY, 1996, 41 (04) : 1149 - 1153
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