Submicrometer metallic barcodes

被引：1195

作者：

Nicewarner-Peña, SR

Freeman, RG

Reiss, BD

He, L

Peña, DJ

Walton, ID

Cromer, R

Keating, CD ^{[1
]}

Natan, MJ

机构：

[1] Penn State Univ, Dept Chem, Davey Lab 152, University Pk, PA 16802 USA

[2] SurroMed Inc, Mt View, CA 94043 USA

来源：

SCIENCE | 2001年 / 294卷 / 5540期

关键词：

D O I：

10.1126/science.294.5540.137

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We synthesized multimetal microrods intrinsically encoded with submicrometer stripes. Complex striping patterns are readily prepared by sequential electrochemical deposition of metal ions into templates with uniformly sized pores. The differential reflectivity of adjacent stripes enables identification of the striping patterns by conventional tight microscopy. This readout mechanism does not interfere with the use of fluorescence for detection of analytes bound to particles by affinity capture, as demonstrated by DNA and protein bioassays.

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页码：137 / 141

页数：5

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