Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome

被引:177
作者
Nuojua-Huttunen, S
Tomas, C
Bloigu, R
Tuomivaara, L
Martikainen, H
机构
[1] Family Federat Finland, Oulu Infertil Clin, FIN-90220 Oulu, Finland
[2] Oulu Univ Hosp, Dept Obstet & Gynecol, FIN-90220 Oulu, Finland
[3] Oulu Univ, Fac Med, FIN-90220 Oulu, Finland
关键词
clomiphene citrate; human menopausal gonadotrophin; infertility; intrauterine insemination; prognostic factors;
D O I
10.1093/humrep/14.3.698
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
A total of 811 intrauterine insemination (IUI) cycles in which clomiphene citrate/human menopausal gonadotrophin (HMG) was used for ovarian stimulation were analysed retrospectively to identify prognostic factors regarding treatment outcome. The overall pregnancy rate was 12.6% per cycle, the multiple pregnancy rate 13.7%, and the miscarriage rate 23.5%. Logistic regression analysis revealed five predictive variables as regards pregnancy: number of the treatment cycle (P = 0.009), duration of infertility (P = 0.017), age (P = 0.028), number of follicles (P = 0.031) and infertility aetiology (P = 0.045). The odds ratios for age <40 years, unexplained infertility aetiology (versus endometriosis) and duration of infertility less than or equal to 6 years were 3.24, 2.79 and 2.33, respectively. A multifollicular ovarian response to clomiphene citrate/HMG resulted in better treatment success than a monofollicular response, and 97% of the pregnancies were obtained in the first four treatment cycles. The results indicate that clomiphene citrate/HMG/IUI is a useful and cost-effective treatment option in women <40 years of age with infertility duration less than or equal to 6 years, who do not suffer from endometriosis.
引用
收藏
页码:698 / 703
页数:6
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