Chagas Heart Disease Report on Recent Developments

被引：65

作者：

Machado, Fabiana S. ^{[1
,2
]}

Jelicks, Linda A. ^{[3
,4
]}

Kirchhoff, Louis V. ^{[5
,6
,7
]}

Shirani, Jamshid ^{[8
]}

Nagajyothi, Fnu ^{[9
]}

Mukherjee, Shankar ^{[9
]}

Nelson, Randin ^{[9
]}

Coyle, Christina M. ^{[10
,11
]}

Spray, David C. ^{[12
]}

Campos de Carvalho, Antonio C. ^{[12
,13
,14
]}

Guan, Fangxia ^{[15
]}

Prado, Cibele M. ^{[16
]}

Lisanti, Michael P. ^{[17
,18
]}

Weiss, Louis M. ^{[9
,10
,11
,19
]}

Montgomery, Susan P. ^{[20
]}

Tanowitz, Herbert B. ^{[9
,10
,11
,19
]}

机构：

[1] Univ Fed Minas Gerais, Dept Biochem & Immunol, Inst Biol Sci, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG, Brazil

[3] Albert Einstein Coll Med, Gruss Magnet Resonance Res Ctr, Bronx, NY 10461 USA

[4] Albert Einstein Coll Med, Dept Physiol & Biophys, Bronx, NY 10461 USA

[5] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

[6] Univ Iowa, Dept Epidemiol, Iowa City, IA USA

[7] Dept Vet Affairs Med Ctr, Iowa City, IA 52242 USA

[8] St Lukes Hosp & Hlth Network, Dept Cardiol, Bethlehem, PA USA

[9] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA

[10] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[11] Jacobi Med Ctr, Dept Parasitol, Bronx, NY USA

[12] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10461 USA

[13] Natl Cardiol Inst, Rio De Janeiro, Brazil

[14] Univ Fed Rio de Janeiro, Inst Biophys, BR-21941 Rio De Janeiro, Brazil

[15] Zhengzhou Univ, Dept Bioengn, Zhengzhou, Peoples R China

[16] Univ Sao Paulo, Dept Pathol, BR-14049 Ribeirao Preto, Brazil

[17] Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[18] Thomas Jefferson Univ, Dept Stem Cell Biol & Regenerat Med, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[19] Albert Einstein Coll Med, Global Hlth Ctr, Bronx, NY 10461 USA

[20] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA

来源：

CARDIOLOGY IN REVIEW | 2012年 / 20卷 / 02期

关键词：

Trypanosoma cruzi; Chagas disease; nifurtimox; benznidazole; heart transplantation; echocardiogram; cardiac magnetic resonance imaging; TRYPANOSOMA-CRUZI INFECTION; CARDIAC MAGNETIC-RESONANCE; TERT-BUTYL-NITRONE; UNITED-STATES; MURINE MODEL; MITOCHONDRIAL DYSFUNCTION; CONGENITAL TRANSMISSION; MYOCARDIAL STRUCTURE; NATRIURETIC PEPTIDE; OXIDATIVE STRESS;

D O I：

10.1097/CRD.0b013e31823efde2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythmias, cardioembolism, and stroke. Clinical and laboratory-based research to define the pathology resulting from T. cruzi infection has shed light on many of the cellular and molecular mechanisms leading to these manifestations. Antiparasitic treatment may not be appropriate for patients with advanced cardiac disease. Clinical management of Chagas heart disease is similar to that used for cardiomyopathies caused by other processes. Cardiac transplantation has been successfully performed in a small number of patients with Chagas heart disease.

引用

页码：53 / 65

页数：13

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