Short Review on Sublingual Immunotherapy for Patients with Allergic Rhinitis: from Bench to Bedside

被引：0

作者：

Kawauchi, Hideyuki ^{[1
]}

Goda, Kaoru ^{[1
]}

Tongu, Miki ^{[1
]}

Yamada, Takaya ^{[1
]}

Aoi, Noriaki ^{[1
]}

Morikura, Ichiro ^{[1
]}

Fuchiwaki, Takashi ^{[1
]}

机构：

[1] Shimane Univ, Fac Med, Dept Otorhinolaryngol, Izumo, Shimane 6938501, Japan

来源：

RECENT ADVANCES IN TONSILS AND MUCOSAL BARRIERS OF THE UPPER AIRWAYS | 2011年 / 72卷

关键词：

MECHANISMS; CELLS;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sublingual immunotherapy has been considered to be a painless and effective therapeutic treatment for allergic rhinitis, and is known as type 1 allergy of the nasal mucosa. So far, its mechanism of action has been elucidated employing peripheral blood serum and lymphocytes in an antigen-specific fashion. Because of the limitations in sampling human materials, there is still controversy among many reports between clinical efficacy and laboratory data. Therefore, its mechanism of action needs to be investigated further by using promising animal models such as rodents and monkeys. Bearing this in mind, in our present study, we successfully constructed an effective murine model for sublingual immunotherapy in allergic rhinitis in which mice were administered ovalbumin (OVA) sublingually followed by intraperitoneal sensitization and nasal challenge. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：103 / 106

页数：4

共 10 条

[1] Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation [J].