A new enantioselective catalytic route to Florhydral®

被引：20
作者：
Bovo, Sara [1 ]
Scrivanti, Alberto [1 ]
Bertoldini, Matteo [1 ]
Beghetto, Valentina [1 ]
Matteoli, Ugo [1 ]
机构：
[1] Univ Venice, Dipartimento Chim, I-30123 Venice, Italy
来源：
SYNTHESIS-STUTTGART | 2008年 / 16卷 / 16期
关键词：
enantioselective hydrogenation; asymmetric catalysis; iridium; fragrance asymmetric synthesis; chiral fragrances;
D O I：
10.1055/s-2008-1067167
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The valuable fragrance Florhydral (R) [3-(3-isopropylphenyl)butanal] has been synthesized in almost enantiomerically pure form by a new catalytic route. The key step of the process is the enantioselective hydrogenation of (E)-3-(3-isopropylphenyl)but-2-en-l-ol, which is carried out with asymmetric inductions of up to 97% using an iridium-phosphinooxazoline chiral catalyst.
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收藏
页码：2547 / 2550
页数：4
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