Synthesis and in vitro antimicrobial studies of thiodihydropyrimidine derivatives

被引：3

作者：

Pasupathi, Mani ^{[1
]}

Santhi, Namasivayam ^{[1
]}

Venkatesan, Kasi ^{[2
]}

机构：

[1] Govt Arts Coll, Dept Chem, PG & Res, Chidambaram, Tamil Nadu, India

[2] CVR Coll Engn, Dept Humanities & Sci, Vastunagar, Telangana, India

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2020年 / 67卷 / 06期

关键词：

antibacterial; antifungal; thiodihydropyrimidine; BIOLOGICAL EVALUATION; PYRIMIDINE-DERIVATIVES; AGENTS; ANTIPLATELET; DESIGN; SAR;

D O I：

10.1002/jccs.201900197

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present study, a series of thiodihydropyrimidine derivatives were synthesized from different substituted aromatic aldehydes, ethyl acetoacetate, and urea/thiourea using a bimetallic TUD-1 catalyst. The structures of all the synthesized compounds were characterized by melting point determination, thin layer chromatography (TLC), infrared (IR),(HNMR)-H-1, and(13)C-NMR values. All the synthesized compounds were screened for their antimicrobial activities against two gram positive bacteria, two-gram negative bacteria, and two fungal strains.

引用

页码：1113 / 1119

页数：7

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