Randomized trial of Tibetan yoga in patients with breast cancer undergoing chemotherapy

被引:84
作者
Chaoul, Alejandro [1 ]
Milbury, Kathrin [1 ]
Spelman, Amy [1 ]
Basen-Engquist, Karen [2 ]
Hall, Martica H. [3 ]
Wei, Qi [1 ]
Shih, Ya-Chen Tina [4 ]
Arun, Banu [5 ]
Valero, Vicente [5 ]
Perkins, George H. [6 ]
Babiera, Gildy V. [7 ]
Wangyal, Tenzin [8 ]
Engle, Rosalinda [1 ]
Harrison, Carol A. [2 ]
Li, Yisheng [9 ]
Cohen, Lorenzo [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, 1400 Holcombe Blvd,Unit 462, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Behav Sci, Houston, TX 77030 USA
[3] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Hlth Serv Res, Houston, TX 77030 USA
[5] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77030 USA
[6] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
[7] Univ Texas MD Anderson Canc Ctr, Dept Breast Surg Oncol, Houston, TX 77030 USA
[8] Ligmincha Inst, Shipman, VA USA
[9] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
breast cancer; chemotherapy; patients; sleep quality; Tibetan yoga; QUALITY-OF-LIFE; SLEEP QUALITY; FATIGUE; WOMEN; SURVIVORS; PROGRAM; DEPRESSION; SURGERY; SYSTEM; IMPACT;
D O I
10.1002/cncr.30938
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: The current randomized trial examined the effects of a Tibetan yoga program (TYP) versus a stretching program (STP) and usual care (UC) on sleep and fatigue in women with breast cancer who were undergoing chemotherapy. METHODS: Women with stage (American Joint Committee on Cancer (AJCC) TNM) I to III breast cancer who were undergoing chemotherapy were randomized to TYP (74 women), STP (68 women), or UC (85 women). Participants in the TYP and STP groups participated in 4 sessions during chemotherapy, followed by 3 booster sessions over the subsequent 6 months, and were encouraged to practice at home. Self-report measures of sleep disturbances (Pittsburgh Sleep Quality Index), fatigue (Brief Fatigue Inventory), and actigraphy were collected at baseline; 1 week after treatment; and at 3, 6, and 12 months. RESULTS: There were no group differences noted in total sleep disturbances or fatigue levels over time. However, patients in the TYP group reported fewer daily disturbances 1 week after treatment compared with those in the STP (difference, -0.43; 95% confidence interval [95% CI], -0.82 to -0.04 [P=.03]) and UC (difference, -0.41; 95% CI, -0.77 to -0.05 [P=.02]) groups. Group differences at the other time points were maintained for TYP versus STP. Actigraphy data revealed greater minutes awake after sleep onset for patients in the STP group 1 week after treatment versus those in the TYP (difference, 15.36; 95% CI, 7.25-23.48 [P=.0003]) and UC (difference, 14.48; 95% CI, 7.09-21.87 [P=.0002]) groups. Patients in the TYP group who practiced at least 2 times a week during follow-up reported better Pittsburgh Sleep Quality Index and actigraphy outcomes at 3 months and 6 months after treatment compared with those who did not and better outcomes compared with those in the UC group. CONCLUSIONS: Participating in TYP during chemotherapy resulted in modest short-term benefits in sleep quality, with long-term benefits emerging over time for those who practiced TYP at least 2 times a week. Cancer 2018;124:36-45. (c) 2017 American Cancer Society.
引用
收藏
页码:36 / 45
页数:10
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