Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Their Correlation with Neuronal Intracellular Calcium Signals

被引：90

作者：

He, Yi ^{[1
,2
]}

Wang, Maosen ^{[1
,2
]}

Chen, Xuming ^{[1
,2
]}

Pohmann, Rolf ^{[1
]}

Polimeni, Jonathan R. ^{[3
]}

Scheffler, Klaus ^{[1
,6
]}

Rosen, Bruce R. ^{[3
]}

Kleinfeld, David ^{[4
,5
]}

Yu, Xin ^{[1
]}

机构：

[1] Max Planck Inst Biol Cybernet, High Field Magnet Resonance Dept, D-72076 Tubingen, Germany

[2] Univ Tubingen, Int Max Planck Res Sch, Grad Training Ctr Neurosci, D-72074 Tubingen, Germany

[3] Harvard Med Sch, Massachusetts Gen Hosp, MGH MIT HMS Athinoula A Martinos Ctr Biomed Imagi, Dept Radiol, Charlestown, MA 02114 USA

[4] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Neurobiol Sect, La Jolla, CA 92093 USA

[6] Univ Tubingen, Dept Biomed Magnet Resonance, D-72076 Tubingen, Germany

来源：

NEURON | 2018年 / 97卷 / 04期

关键词：

RESTING-STATE FMRI; RAT SOMATOSENSORY CORTEX; INDEPENDENT COMPONENT ANALYSIS; FUNCTIONAL MRI; NEURAL ACTIVITY; BLOOD-FLOW; VISUAL-CORTEX; 9.4; T; SPONTANEOUS FLUCTUATIONS; CEREBRAL HEMODYNAMICS;

D O I：

10.1016/j.neuron.2018.01.025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Functional MRI has been used to map brain activity and functional connectivity based on the strength and temporal coherence of neurovascular-coupled hemodynamic signals. Here, single-vessel fMRI reveals vessel-specific correlation patterns in both rodents and humans. In anesthetized rats, fluctuations in the vessel-specific fMRI signal are correlated with the intracellular calcium signal measured in neigh-boring neurons. Further, the blood-oxygen-level-dependent (BOLD) signal from individual venules and the cerebral-blood-volume signal from individual arterioles show correlations at ultra-slow (< 0.1 Hz), anesthetic-modulated rhythms. These data support a model that links neuronal activity to intrinsic oscillations in the cerebral vasculature, with a spatial correlation length of similar to 2 mm for arterioles. In complementary data from awake human subjects, the BOLD signal is spatially correlated among sulcus veins and specified intracortical veins of the visual cortex at similar ultra-slow rhythms. These data support the use of fMRI to resolve functional connectivity at the level of single vessels.

引用

页码：925 / +

页数：20

共 77 条

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