Challenges, applications and future directions of precision medicine in prostate cancer - the role of organoids and patient-derived xenografts

被引:12
作者
Joshi, Andre [1 ,2 ,3 ,4 ,5 ]
Roberts, Matthew J. [1 ,6 ,7 ]
Alinezhad, Saeid [2 ,3 ,4 ]
Williams, Elizabeth D. [2 ,3 ,4 ]
Vela, Ian [1 ,2 ,3 ,4 ,5 ]
机构
[1] Princess Alexandra Hosp, Dept Urol, Brisbane, Qld, Australia
[2] Australian Prostate Canc Res Ctr Queensland, Brisbane, Qld, Australia
[3] Translat Res Inst, Brisbane, Qld, Australia
[4] Queensland Univ Technol QUT, Sch Biomed Sci, Brisbane, Qld, Australia
[5] Univ Queensland, Fac Med, Brisbane, Qld, Australia
[6] Univ Queensland, Clin Res Ctr, Herston, Qld, Australia
[7] Royal Brisbane & Womens Hosp, Dept Urol, Herston, Qld, Australia
关键词
prostatic neoplasms; precision medicine; cell lines; organoids; patient-derived xenografts; drug screening; CARCINOMA-CELL-LINE; STEM-CELLS; IN-VITRO; ESTABLISHMENT; DIFFERENTIATION; IDENTIFICATION; METABOLOMICS; RESISTANCE; MUTATIONS; MODELS;
D O I
10.1111/bju.15103
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective To provide a clinically relevant outline of various current precision medicine principles and available evidence on the application and potential for a precision medicine approach in prostate cancer. Methods Narrative review of the current literature in the field. Conclusion Precision medicine is the concept of individualising patient management based on specific tumour characteristics and biology, rather than traditional histological subtypes. The overall aim is to personalise management to individual patients, to provide the right cancer treatment, to the right patient, at the right time. While the approach aims to improve clinical outcomes, decrease morbidity and improve survival in men with advanced prostate cancer, its clinical application is in its infancy. It does however show great promise in this and other cancers, and will continue to be an area of active research and clinical investigation.
引用
收藏
页码:65 / 72
页数:8
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