Unequal tissue expression of proteins from the PA/PAI system, myoma necrosis, and uterus survival after uterine artery occlusion

被引：12
作者：
Cheng, Zhongping [1 ]
Xie, Yan [1 ]
Dai, Hong [1 ]
Hu, Liping [1 ]
Zhu, Yu [1 ]
Gong, Jun [1 ]
机构：
[1] Yangpu Dist Cent Hosp, Dept Obstet & Gynecol, Shanghai 200090, Peoples R China
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2008年 / 102卷 / 01期
关键词：
myoma; plasminogen activator; inhibitor type 1; tissue plasminogen activator; urokinase plasminogen activator; uterine artery occlusion;
D O I：
10.1016/j.ijgo.2008.02.006
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To further the understanding of the mechanism behind myoma necrosis and uterus survival after uterine artery occlusion. Method: Myomal. and myometrial gene transcription and protein expression of tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), and plasminogen activator inhibitor type 1 (PAI-1) were investigated in 30 uteri. Results: Compared with myometrial expression, myomal expression was Less for uPA mRNA (1.34% +/- 2.18% vs 2.84% +/- 2.97%; P<0.05) and greater for PAI-1 mRNA (2.67% +/- 1.82% vs 1.27% +/- 1.99%; P<0.05), but the difference in tPA mRNA expression was not significant. Accordingly, compared with myometrial expression, myomal expression was less for the uPA protein (P<0.05) and greater for the PAI-1 protein (P<0.05), but the difference in tPA protein was not significant. Conclusion: The PA/PAI system was found to be expressed differently in myomas and the myometrium, which may play a rote in uterus survival and myoma necrosis after uterine artery occlusion. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：55 / 59
页数：5
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