Difluorphos, an electron-poor diphosphane: A good match between electronic and steric features

被引：233
作者：
Jeulin, S
de Paule, SB
Ratovelomanana-Vidal, V
Genet, JP
Champion, N
Dellis, P
机构：
[1] Ecole Natl Super Chim Paris, Lab Synth Select Organ & Prod Nat, F-75231 Paris 05, France
[2] SYNKEM SAS, F-21301 Chenove, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 03期
关键词：
asymmetric catalysis; atropisomerism; fluorinated ligands; hydrogenation; ruthenium;
D O I：
10.1002/anie.200352453
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The π acidity makes the difference: The fluorinated diphosphane, difluorphos, is synthesized (see structure: purple = P, red = O, green = F, gray = C) and its stereoelectronic features are evaluated in theoretical and experimental studies. Its unusual π acidity explains the excellent results obtained with it in ruthenium-mediated asymmetric hydrogenation of fluorinated β-functionalized ketones. These results are better than those obtained with other biphenyl-based diphosphanes.
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页码：320 / 325
页数：6
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