Genetic variations in the ADCK1 gene predict paliperidone palmitate efficacy in Han Chinese patients with schizophrenia

被引：6
作者：
Su, Yun-Ai [1 ,2 ,3 ,4 ]
Bousman, Chad [5 ,6 ,7 ]
Li, Qian [1 ,2 ,3 ,4 ]
Li, Ji-Tao [1 ,2 ,3 ,4 ]
Lin, Jing-Yu [1 ,2 ,3 ,4 ]
Si, Tian-Mei [1 ,2 ,3 ,4 ]
机构：
[1] Peking Univ, Hosp 6, Beijing 100191, Peoples R China
[2] Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
[3] Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
[4] Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
[5] Univ Calgary, Dept Med Genet, Calgary, AB T2N 4N1, Canada
[6] Univ Calgary, Dept Psychiat, Calgary, AB T2N 4N1, Canada
[7] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1, Canada
来源：
JOURNAL OF NEURAL TRANSMISSION | 2019年 / 126卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Schizophrenia; Paliperidone palmitate; ADCK1; Pharmacogenetics; EXTENDED-RELEASE TABLETS; PHARMACOGENETICS; ASSOCIATION; TOLERABILITY; RISPERIDONE; 6-WEEK; SAFETY;
D O I：
10.1007/s00702-018-1953-6
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Genome-wide association study results have linked ADCK1 genetic variation with paliperidone efficacy in a European cohort. However, the generalizability of this locus to non-European populations is unknown. Han Chinese schizophrenia patients (n=159) were treated with paliperidone palmitate and symptom severity was assessed over 3months. Examination of 13 ADCK1 genetic variants revealed two single nucleotide polymorphisms (rs12590199, rs11159291) and one haplotype (rs2364747-rs12590199) associated with paliperidone palmitate response. Future work into ADCK1's function and its potential interaction with paliperidone is warranted.
引用
收藏
页码：19 / 25
页数：7
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